| Título: | Fluorometric microdetermination of estrogens in the plasma of non-pregnant women with breast cancer |
| Autores: | Kalomiris, Constantinos |
| Fecha: | Browne, J. |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Electronic Thesis or Dissertation |
| Tema: | Experimental Medicine. |
| Descripción: | Plasma levels of three estrogens, namely, estrone, estradiol and estriol in 32 patients with breast cancer and 8 normal subjects were determined fluorometrically by using a method developed by Brown as modified by Roy. The results obtained indicate that there is no significant difference between the mean plasma levels of estrone and estradiol in the two groups. The plasma estriol, however, is considerably higher in the breast cancer patients. This elevated estriol suggests an increased activity in estrogen metabolism. An attempt was made to determine the site of this increased activity in three patients with breast cancer by measuring the estrogen level in the peripheral plasma and in mammary vein plasma obtained during mastectomy. Comparison of the values obtained for each patient suggests that the mammary tumor is not the site of increased metabolic activity. When the mean plasma estrogen levels of breast cancer patients were compared to those found in patients with metastatic cancer (Table X1), no significant difference was found between the two groups. The foregoing work indicates that it is not justifiable to conclude that the metabolic disorder of estrogens noted in patients with breast cancer is peculiar to this specific disease until sufficient knowledge exists regarding estrogen metabolism in other diseases. |
| Idioma: | en |
1 Investigations on the form-genera Beauveria and Tritirachium por MacLeod, Donald Murdock | 6 Treatment and recovery in first-episode psychosis : a qualitative analysis of client experiences por Windell, Deborah L. |
2 Seismic sensitivity of tall guyed telecommunication towers. por Ghodrati Amiri, Gholamreza. | 7 |
3 Exploring the Relationship Between Assets and Family Stress Among Low-Income Families por Rothwell, David W.,Han, Chang-Keun | 8 |
4 The case for asset-based interventions with indigenous peoples: Evidence from Hawai‘i por Rothwell, David W. | 9 |
5 Second Thoughts: Who Almost Participates in an IDA Program? por Rothwell, David W.,Han, Chang-Keun | 10 Recent contributions to the phenomenology of musical time : a critical survey por Beaudreau, Pierre |