| Título: | The metabolism of tritium-labelled folic acid in man. |
| Autores: | Johns, David. G. |
| Fecha: | 1963 |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Electronic Thesis or Dissertation |
| Tema: | Biochemistry. |
| Descripción: | The beginning of our knowledge of the vitamin folic acid dates back to the discovery of Wills (1) in 1931 that the macrocytic anemia of pregnancy frequently observed in the tropics responded to oral administration of concentrated extracts of autolysed yeast. This tropical anemia resembled classical Addisonian pernicious anemia in that the bone marrow exhibited megaloblastic changes, but differed from true pernicious anemia in that achlorhydria and neurological changes were absent. A considerable advance was made in the characterization of the unknown hematopoietic factor when it was found by Wills and Stewart (2) that a similar syndrome could be induced in monkeys by feeding a diet similar to that common in those areas of India where the disease was frequent. |
| Idioma: | en |
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