Diabetes mellitus represents a serious public health problem owing to its global prevalence in the last decade. The causes of this metabolic disease include dysfunction and/or insufficient number of b cells. Existing diabetes mellitus treatments do not reverse or control…

The Caribbean Basin has complex biogeographical and cultural histories that have shaped its highly diverse botanical and cultural landscapes. As a result, the current ethnic composition of the Basin is a heterogeneous mixture including Amerindian, Afrocaribbean and a wide range…

NAC proteins constitute one of the largest groups of plant-specific transcription factors and are known to play essential roles in various developmental processes. They are also important in plant responses to stresses such as drought, soil salinity, cold, and heat,…

Knowledge on the biosynthetic pathways of the monoter­pene alkaloids is enormous, but little is known about their mechanism of transporting system from the plant cell. There is not concrete evi­dence confirming the role of ABC transporters in the secretion of monoterpene indole alkaloids (MIAs) in Catharanthus roseus. There­fore, in order to determine the role of different transporting systemsinvolved in the MIAs translocation, we employed…

La separación de biomoléculas de alto valor añadido, con tamaño y características similares como la albúmina de suero bovino (BSA) y la lactoferrina (LF), representa uno de los retos más difíciles en la industria bioquímica. Durante 100 años las técnicas…

Breast Cancer Resistance Protein (BCRP, ABCG2) and P-glycoprotein (P-gp, ABCB1, MDR1) are
members of the G and B subfamily of the ATP-binding cassette (ABC) efflux transporters, respectively.
Both transporters use the energy of ATP hydrolysis for substrate efflux.…

En esta tesis doctoral se propone la utilización de una metodología espacial para la integración de construcciones rurales en su entorno, mediante la utilización de un sistema de evaluación de criterios múltiples (ECM), en un entorno web asistido por la…

Generally, drilling fluids may be multicomponent suspensions, emulsions and/or foams, basically consisting of a base fluid (oil or water), viscosifiers/thinners (clays, biopolymers, etc) and weighting agents (salts) designed to lubricate during drilling operation and removal the cuttings, among others functions.…

In this article we study the retrospective inverse problem. The retrospective inverse problem consists of in the reconstruction of a priori unknown initial condition of the dynamic system from its known final condition. Existence and uniqueness of the solution is…

Research studying effective planning and optimization in the vehicle routing field has increased tremendously in the last few decades. Advances in technology and computational power have encouraged researchers to consider various vehicle routing problem types and constraints, and to experiment…