In this dissertation I examine the conceptions of opinion (<italic>doxa</italic>}), knowledge (<italic>gnosis</italic>), and understanding (<italic>episteme</italic>) that are presented by the character Socrates in Plato's <italic>Meno</italic> and <italic>Republic</italic>. A central claim I make, and one that sets my interpretation apart from…

This dissertation is a history of astronomy in three cultural locations in late Ottoman Egypt: the scholarly culture of Muslim ulama, the state institution of the Viceregal Observatory, and the Arabic press. Through an interwoven history of these cultures, the…

This dissertation focuses on the specific strategies by which authors of the travel writing genre seize narrative agency. Throughout its centuries-long history, the genre of travel writing has offered multiple generations of authors a means by which to convey observations…

The United States is struggling to provide health care in the face of ever increasing demand. As medical students continue their decades long march toward specialization, questions of how to provide generalist care become quickly intertwined with that of who…

During the twentieth century, tobacco farmers in rural North Carolina quietly changed the relationship between the government and citizen in America . Flue-cured tobacco growers produced not only the finest cigarette leaf, but also new systems of marketing, regulating, and…

This dissertation studies nonlinear panel data models with multiple fixed effects. The first two chapters consider the adaptability of estimation methods for nonlinear panel data models to multiple fixed effects. The first chapter investigates whether existing methods can be modified…

Network-based modeling of complex systems with emergent behavior is increasingly being employed across different disciplines. Much of the focus in such efforts has been on detailed, "microscopic" modeling, in which the dynamics is described in terms of the individual nodes…

Protein domain prediction is a key step in characterizing protein structure, function, and evolution. However, the genome of Plasmodium falciparum, the causative agent of malignant malaria, remains poorly-annotated using standard approaches to domain prediction. We identified several general problems with…

Human cells are protected by cell-intrinsic mechanisms that specifically detect microbial pathogens and elicit innate immune response. Such activities are essential in restricting viral infections. Despite the extensive knowledge about cytoplasmic sensing processes, little is understood about the nuclear counterpart.…

In this thesis we develop and test methods for numerically evolving hydrodynamics coupled to the Einstein field equations, and then apply them to several problems in gravitational physics and astrophysics. The hydrodynamics scheme utilizes high-resolution shock-capturing techniques with flux corrections…