The role of prion protein (PrPC) as a crucial factor in the pathogenesis of the Transmissible Spongiform Encephalopathies (TSE's) is well known. However, the physiologic role of this highly conserved protein in vivo is thus far, largely unknown. In vitro…

Aminoglycosides are broad spectrum antibiotics that act by binding to 16S rRNA of bacteria. The wide spread of aminoglycoside resistance threatens the use of these important medicines. Two general approaches can be used to address the aminoglycoside resistance problem. One…

Markov Decision Processes are a mathematical framework widely used for stochastic optimization and control problems. Reinforcement Learning is a branch of Artificial Intelligence that deals with stochastic environments where the dynamics of the system are unknown. A major issue for…

Good command of anatomy is a basic requirement for studying and practicing clinical disciplines. A common difficulty that faces many medical and dental students (at least this was the case with the author) is how to keep their knowledge of…

The way frailty is conceptualised and interpreted has profound implications for social responses, care practice and the personal experience of care. This paper begins with an exegesis of the concept of frailty, and then examines the dominant notions of frailty,…