The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally believes that a greater integration of drug…

This thesis presents research about the potential business impacts of the Semantic Web. The concept of the Semantic Web is an expansion of the Web for computers, enabling them to comprehend the meaning of information. In addition, Semantic Web Services…

This thesis proposes a miethodology for the design of man-machine interfaces by combining top-down and bottom-up processes in vision. From a computational perspective, we propose that the scientific-cognitive question of combining top-down and bottom-up knowledge is similar to the engineering…

Building energy simulation (ES) and computational fluid dynamics (CFD) can play important roles in building design by providing essential information to help design energy-efficient, thermally comfortable and healthy buildings. However, separate applications of ES and CFD usually cannot give an…

Background: Local adaptation of guidelines may increase compliance with guidelines that have been developed at a national level and are often not used in practice because of contextual factors. We have developed a representation scheme known as HieroGLIF, that facilitates…

(cont.) which are then applied to developmentally acquire new object representations. The humanoid robot therefore sees the world through the caregiver's eyes. Building an artificial humanoid robot's brain, even at an infant's cognitive level, has been a long quest which…

Chapter 1. Molybdenum Dinitrogen Chemistry: Formation and Reactivity of (Ar[tBu]N)3MoN2- A collection of (Ar[tBu]N)3MoN2- compounds, supported with Na+, K+, Mg2+ and Ca2+ have been prepared through a variety of synthetic routes. In several experiments, N2 was replaced with other small…

Increasingly, knowledge-based tasks such as new product development and market research are being conducted by geographically dispersed teams. Early evidence from knowledge-based view of the firm and geographically dispersed work literatures suggests that at least four kinds of knowledge gaps---transactive…

Knowledge-based Cascade-correlation is a neural network algorithm that combines inductive learning and knowledge transfer (Shultz & Rivest, 2001). In the present thesis, this algorithm is tested on several real-world and artificial problems, and extended in several ways. The first extension…

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