In this note, I propose two extensions to the Java virtual machine (or VM) to allow dynamic languages such as Dylan, Scheme and Smalltalk to be efficiently implemented on the VM. These extensions do not affect the performance of pure…

Java 1.5 will include a type system (called JSR-14) that supports parametric polymorphism, or generic classes. This will bring many benefits to Java programmers, not least because current Java practise makes heavy use of logically-generic classes, including container classes. Translation…

Region-based memory management offers several important advantages over garbage-collected heap, including real-time performance, better data locality and efficient use of limited memory. The concept of regions was first introduced for a call-by-value functional language by Tofte and Talpin, and has…

The next generations of both biological engineering and computer engineering demand that control be exerted at the molecular level. Creating, characterizing and controlling synthetic biological systems may provide us with the ability to build cells that are capable of a…

Three-dimensional route maps, which depict a path from one location to another, can be powerful tools for visualizing and communicating directions. This thesis presents a client-server architecture for generating and displaying accurate, usable route maps between locations on MIT's campus.…

The emergence of industry standards often has disruptive impacts on the behavior of markets. It can drive commoditization, substitution and convergence. It also changes the industry structure creating new business models and value chains, coupled with the entrance of new…

Over the past several years, the explosive growth of biological data generated by new high-throughput instruments has virtually begun to drown the biological community. There is no established infrastructure to deal with these data in a consistent and successful fashion.…

This thesis describes a framework for collecting, analyzing, and visualizing dynamic data, particularly data gathered through Web questionnaires. The framework addresses challenges such as promoting user participation, handling missing or invalid data, and streamlining the data interpretation process. Tools in…

The next generations of both biological engineering and computer engineering demand that control be exerted at the molecular level. Creating, characterizing and controlling synthetic biological systems may provide us with the ability to build cells that are capable of a…

This paper describes the design and implementation of MATLAB*G, a parallel MATLAB on the ALiCE Grid. ALiCE (Adaptive and scaLable internet-based Computing Engine), developed at NUS, is a lightweight grid-computing middleware. Grid applications in ALiCE are written in Java and…