Murine acquired immune deficiency syndrome (MAIDS) shares several common characteristics with human AIDS, including immunodeficiency, hypergammaglobulinemia, susceptibility to infection, both B and T cell dysfunctions, lymphadenopathy, splenomegaly and aberrant cytokine production. The etiologic agent of MAIDS has been identified as…

Introduction. Most patients with early-stage endometrial carcinoma are treated with hysterectomy. The knowledge of the stage of disease could impact greatly on the eventual therapeutic decision. Numerous studies have investigated the use of endovaginal ultrasonography (US) and magnetic resonance (MR)…

This thesis explores the role of an adhesion protein, CD44, in the biology of colon cancer. CD44 glycoprotein is a main extracellular receptor for hyaluronic acid. A single CD44 gene composed of 20 exons encodes a variety of isoforms due…

Breast cancer is the second most frequent cancer in middle-aged women. Control of this disease requires identification of the various factors involved in the invasive-metastatic cascade, facilitating the subsequent development of relevant blocking compounds., Tumor cell invasion is a complex…

The studies included in this thesis were aimed at identifying the mechanisms that lead to aberrant expression of the PTHRP gene in cancer., We have used the hepatocyte growth factor receptor oncogene, Tpr-Met, as a model and examined the effect…