Murine acquired immune deficiency syndrome (MAIDS) shares several common characteristics with human AIDS, including immunodeficiency, hypergammaglobulinemia, susceptibility to infection, both B and T cell dysfunctions, lymphadenopathy, splenomegaly and aberrant cytokine production. The etiologic agent of MAIDS has been identified as…

The study of how antigens and superantigens are presented to T cell has always been a great challenge to immunologists. Mainly because the understanding of how subtle changes in the interaction of the T cell receptor (TCR) with its ligands…

The concentration of extracellular ionized calcium (Ca2+ o) is the primary physiological regulator of parathyroid hormone (PTH) secretion. The parathyroid gland has a special ability to sense extracellular the calcium concentration and the mechanism whereby this is achieved became clearer…

Nerve growth factor (NGF) belongs to the neurotrophin family of growth factors. NGF can bind to two transmembrane receptors, TrkA and p75. TrkA is the NGF specific tyrosine kinase receptor; p75 is a receptor which is common to all neurotrophins.…

The studies included in this thesis were aimed at identifying the mechanisms that lead to aberrant expression of the PTHRP gene in cancer., We have used the hepatocyte growth factor receptor oncogene, Tpr-Met, as a model and examined the effect…