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The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally believes that a greater integration of drug…

The goal of this paper is to determine if the results for dynamic job-shop scheduling problems are affected by the assumptions made with regard to the processing time distributions and the scheduler's knowledge of the processing times. Three dynamic jobshop…

Compliant control is a standard method for performing fine manipulation tasks, like grasping and assembly, but it requires estimation of the state of contact between the robot arm and the objects involved. Here we present a method to learn a…

We have developed a method and prototype program for assisting two experts in their attempts to construct a single, consensus knowledge base. We show that consensus building can be effectively facilitated by a debugging approach that identifies, explains, and resolves…

Trying to capture intuitive knowledge is a little like trying to capture the moment between what just happened and what is about to happen. Or to quote a famous philosopher, "You can't put your foot in the same river once."…

Reasoning about motion is an important part of our commonsense knowledge, involving fluent spatial reasoning. This work studies the qualitative and geometric knowledge required to reason in a world that consists of balls moving through space constrained by collisions with…

This thesis is concerned with the systematic investigation and application of knowledge within the architectural design studio. The thesis takes, as a point of departure in the development of architectural epistemology, a model of knowledge developed by Yehuda Elkana, in…

An investigation was carried out on the contents of the architectural texts in order to illuminate written architectural knowledge. The thesis takes as its case study the required reading list for Introduction to Architecture course at Yale College, Yale University,…