One important purpose for creating clinical practice guidelines is to improve quality of care by reducing variations in practice. In the current healthcare environment, guidelines are being advocated as a means to disseminate research findings, standardize care, improve quality of…

In systems where agents are required to interact with a partially known and dynamic world, sensors can be used to obtain further knowledge about the environment. However, sensors may be unreliable, that is, they may deliver wrong information (due, e.g.,…

(cont.) as well, firms have an incentive to require coordinated investments in technology across the enterprise. Still, research in IS has also highlighted the fact that the productivity of computer investments is highly dependent on co-investment in complementary assets (for…

The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally believes that a greater integration of drug…

This thesis analyzes how the Auto-ID technology and information infrastructure will change the management and distribution of pharmaceutical products within the health care industry by enabling item level product traceability functionality. The complexity of the health care industry is steadily…

Defeasible Logic Programming (DeLP) is a suitable tool for knowledge representation and reasoning. Its operational semantics is based on a dialectical analysis where arguments for and against a literal interact in order to determine whether this literal is believed by…

Background: Local adaptation of guidelines may increase compliance with guidelines that have been developed at a national level and are often not used in practice because of contextual factors. We have developed a representation scheme known as HieroGLIF, that facilitates…

Firm boundaries have been the subject of much scholarly interest in recent years, as firms increasingly hire external, "contingent" workers and outsource previously core activities. However, little empirical research has directly studied what happens differently inside the firm's boundaries, versus…

(cont.) members. The experimental program for RC beams involves qualitative and quantitative observation of the changes in the debonding behavior and load capacity of the beams with various configurations of shear and/or flexural strengthening and anchorage conditions in four evolutionary…

(cont.) visualize complex geometric arrangements. Finally, the tools developed represent an alternative to what learning technology has always done; transmit academic knowledge to the student. These tools are an example of how IT can be used to go beyond the…