Mutations in the parkin gene are responsible for an early-onset autosomal-recessive form of Parkinson's disease. Parkin is an E3 ubiquitin ligase that acts in the covalent attachment of the small protein ubiquitin to substrate proteins. Although many parkin substrates have…
Fecha:
2006
Recurso:
McGill University - MCGILL
CIC - Centro de Información y Conocimiento Johannes Gutenberg ®