(cont.) which is expected, given their additional knowledge resources. The respondents' urgency in looking for the relevant knowledge is the primary explanation for this difference between the two networks. This difference in knowledge networking among the different groups did not…

One important purpose for creating clinical practice guidelines is to improve quality of care by reducing variations in practice. In the current healthcare environment, guidelines are being advocated as a means to disseminate research findings, standardize care, improve quality of…

(cont.) as well, firms have an incentive to require coordinated investments in technology across the enterprise. Still, research in IS has also highlighted the fact that the productivity of computer investments is highly dependent on co-investment in complementary assets (for…

The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally believes that a greater integration of drug…

This thesis analyzes how the Auto-ID technology and information infrastructure will change the management and distribution of pharmaceutical products within the health care industry by enabling item level product traceability functionality. The complexity of the health care industry is steadily…

(cont.) updates. It produces plan-ready information, by exploiting the self-serving and opportunistic pursuit of instant return-on-investment by frontline offices. Thanks to its emergent qualities, City Knowledge engenders unexpected plan-demanding situations, where the ability to conduct second-order analyses leads to deeper…

(cont.) Packing/Covering problems, we prove upper and lower bounds on the adaptivity gap depending on the dimension. We also design polynomial-time algorithms achieving near-optimal approximation guarantees with respect to the adaptive optimum. Finally, we prove complexity-theoretic results regarding optimal adaptive…

(cont.) and (2) a forward approach which achieves optimality at the start and grows the system using an optimization technique. We systematically compare the two staging techniques in the context of telescope arrays and evaluate the hypothesis that the backward…

Background: Local adaptation of guidelines may increase compliance with guidelines that have been developed at a national level and are often not used in practice because of contextual factors. We have developed a representation scheme known as HieroGLIF, that facilitates…

Firm boundaries have been the subject of much scholarly interest in recent years, as firms increasingly hire external, "contingent" workers and outsource previously core activities. However, little empirical research has directly studied what happens differently inside the firm's boundaries, versus…