The decline in Pharmaceutical R&D productivity has been attributed to high clinical failure rates suggesting that targets, leads and clinical candidates may be of lower quality in recent years. Senior R&D management generally believes that a greater integration of drug…

This thesis presents research about the potential business impacts of the Semantic Web. The concept of the Semantic Web is an expansion of the Web for computers, enabling them to comprehend the meaning of information. In addition, Semantic Web Services…

This thesis proposes a miethodology for the design of man-machine interfaces by combining top-down and bottom-up processes in vision. From a computational perspective, we propose that the scientific-cognitive question of combining top-down and bottom-up knowledge is similar to the engineering…

by Roberta E. Bivins., Thesis (Ph. D.)--Massachusetts Institute of Technology, Program in Science, Technology, and Society, 1997., Includes bibliographical references (leaves 226-237).

by Esther S. Dutton., Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1997., Includes bibliographical references (p. 78).

by Yasuyuki Sekioka., Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1997., Includes bibliographical references (leaves 128-134).

by Sean C. Campbell., Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1997., Includes bibliographical references (p. [85]-87).

by Vuong P. Nguyen., Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997., Includes bibliographical references (leaves 67-68).

Building energy simulation (ES) and computational fluid dynamics (CFD) can play important roles in building design by providing essential information to help design energy-efficient, thermally comfortable and healthy buildings. However, separate applications of ES and CFD usually cannot give an…

Background: Local adaptation of guidelines may increase compliance with guidelines that have been developed at a national level and are often not used in practice because of contextual factors. We have developed a representation scheme known as HieroGLIF, that facilitates…