Nerve growth factor (NGF) belongs to the neurotrophin family of growth factors. NGF can bind to two transmembrane receptors, TrkA and p75. TrkA is the NGF specific tyrosine kinase receptor; p75 is a receptor which is common to all neurotrophins.…

The studies included in this thesis were aimed at identifying the mechanisms that lead to aberrant expression of the PTHRP gene in cancer., We have used the hepatocyte growth factor receptor oncogene, Tpr-Met, as a model and examined the effect…