The synthesis of a GSK 2nd generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between silver(I) and gold(I) catalysts in this reaction was established by…

This paper analyzes how public administration may improve the service it offers to citizens through a suitable organizational culture; for this purpose, it starts by studying the specific features of the culture of public administration. In this respect, it analyzes…

The methods of differential geometry are used with the assumption that rays of light follow geodesic trajectories in a space whose metric is determined by the refraction index. Keeping this in mind, we show that these hypotheses are equivalent to…

3,3'-Bis(dialkylaminomethyl)-1,1'-binaphth-2-ols (Binolams) have emerged during the last five years as very efficient chiral ligands in many enantioselective processes. Enantiomerically pure Binolams are easily accessible by means of a variety of methods, the most widely used being the so-called chiral Binol…

En los últimos veinte años se ha asistido a cambios importantes en la edición de revistas de geografía en España. Ha aumentado notablemente el número de títulos publicados y se ha producido una progresiva y constante adaptación a los criterios…

Nowadays, the analysis of the X-ray spectra of magnetically powered neutron stars or magnetars is one of the most valuable tools to gain insight into the physical processes occurring in their interiors and magnetospheres. In particular, the magnetospheric plasma leaves…

This paper analyzes the efforts made by the Telefonica Group (the main Spanish firm in the telecommunications sector) to evolve from a bureaucratic culture to another oriented towards total quality and the customer. The need for this change came as…

The present work assesses some recently developed double-hybrid density functionals (B2π-PLYP, PBE0-DH, and PBE0-2) using linear-response Tamm-Dancoff Time-Dependent Density Functional Theory. This assessment is achieved against experimentally derived low-lying excitation energies of large organic dyes of recent interest, including some…

The center of our Galaxy hosts a supermassive black hole, Sagittarius (Sgr) A∗. Young, massive stars within 0.5 pc of Sgr A∗ are evidence of an episode of intense star formation near the black hole a few million years ago,…

We report on the long-term X-ray monitoring of the outburst decay of the low magnetic field magnetar SGR 0418+5729 using all the available X-ray data obtained with RXTE, Swift, Chandra, and XMM-Newton observations from the discovery of the source in…