| Título: | Effects of Methadone on Liver Enzymes in Patients Undergoing Methadone Maintenance Treatment |
| Autores: |
Eslami Shahrbabaki, Mahin; Assistant Professor, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Haghdoost, Ali Akbar; Associate Professor, Department of Epidemiology, Health Modeling Research Center, Kerman University of Medical Sciences, Kerman, Iran Mashaiekhi, Azadeh; Psychiatric Assistant, Shahid Beheshiti Hospital, Kerman University of Medical Sciences, Kerman, Iran Khalili, Navid; Psychiatrist, Neuroscience Research Center, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Amini Ranjbar, Zahra; Nurse, Shahid Beheshiti Hospital, Kerman University of Medical Sciences, Kerman, Iran Ghayomi, Alireza; Noor and Aliasghar Hospital, Isfahan University of Medical Sciences, Isfahan, Iran |
| Fecha: | 2012-12-12 |
| Publicador: | Addicition & Health |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | Background: Methadone is currently the most frequently used substance in the treatment of short-term and particularly long-term opiate dependence. Patients' beliefs about the adverse effects of methadone on function of organs, especially liver, have widely affected the use of this substance. This study aimed to determine the effects of methadone on liver enzyme levels in patients on methadone maintenance treatment. Methods: In a retrospective study, a total of 94 patients undergoing methadone maintenance therapy were recruited from Shahid Beheshti Hospital (Kerman, Iran). Liver enzyme levels in all patients were tested every six months from the onset of treatment until 24 months. The relations between test results and age, gender, and methadone dose were then evaluated. Data was analyzed using logistic regression with random data plan. Findings: At the 24th month, alanine aminotransferase (ALT) levels in 4 patients (4.3%) and aspartate aminotransferase (AST) levels in 3 patients (3.2%) were above normal. Among 46 patients (50%) who had normal alkaline phosphatase (ALP) levels after 24 months, 26 subjects were younger than 40 and 20 subjects were over 40 years of age. The mean age of subjects with abnormal ALP levels and the mean methadone dose were 39.9 years and 19.55 cc, respectively.Conclusion: The results of this study indicated the significant effect of methadone on ALP levels. These effects can account for cholestatic pattern liver injury (obstruction). Further prospective studies including greater samples of patients with heart and liver complications and encompassing other drugs are required to confirm our findings.Keywords: Methadone, Substance abuse, Liver, Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase |
| Idioma: | Inglés |
1 Effects of Opium Smoking Cessation on the Nasopharyngeal Microbial Flora por Golshiri, Ali; Assistant Professor of Otorhinolaryngology and Chief of Moradi Hospital, Departments of Otorhinolaryngology, Moradi Hospital, Rafsanjan University of Medical Sciences,Mokhtaree, Mohammad Reza; Hospital Infection Control Nurse, Moradi Hospital, Rafsanjan University of Medical Sciences,Shabani, Ziba; Specialist in Infectious Disease, Ali-ibn- Abitalib Hospital, Rafsanjan University of Medical Sciences,Tabatabaee, Sayed Taghi; Assistant Professor of Pediatrics and Chief of School of Medicine, School of Medicine, Rafsanjan University of Medical Sciences,Rahnama, Amir; Pathologist, Vice Chancellor of Treatment, Rafsanjan University of Medical Sciences,Moradi, Mohammad; Assistant Professor of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences,Sayadi, Ahamad Reza; Ocupational Therapist, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences,Faezi, Hadi; Medical Student, School of Medicine, Rafsanjan University of Medical Sciences | 6 Epidemiologic Study on Drug Abuse among First and Second Grade High School Students in Kerman por Nakhaee, Nouzar; Associate Professor of Community Medicine, School of Medicine, Kerman Neuroscience Research,Ziaaddini, Hassan; Associate Professor of Psychiatry, Kerman University of Medical Sciences,Karimzadeh, Ali; General Physician, Kerman University of Medical Sciences, Kerman |
2 Relationship of Opium Dependency and Stroke por Hamzei Moqaddam, Akbar; Associate Professor of Neurology, School of Medicine, Kerman University of Medical Sciences,Ahmadi Musavi, Seyyed Mohammad Reza; Assistant Professor of Otorhinolaryngology, School of Medicine, Kerman University of Medical Sciences,Khademizadeh, Khatereh; Intern, Shefa Hospital, School of Medicine, Kerman University of Medical Sciences | 7 Prevalence of Cigarette Smoking in Schizophrenic Patients Compared to Other Hospital Admitted Psychiatric Patients por Ziaaddini, Hassan; Associate Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Vahabi, Mostafa; General Practitioner, School of Medicine, Kerman University of Medical Sciences |
3 Opiate Dependents’ Experiences of the Therapeutic Relationship in Methadone Centers; A Qualitative Study por Banazadeh, Nabi; Assistant Professor of Psychiatry, School of Medicine and Neuroscience Research Center, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine and Neuroscience Research Center, Kerman University of Medical Sciences,Abedi, Heidarali; Assistant Professor of Nursing Education, Khorasgan Azad University | 8 Exploit the Developed Countries Experiences of Primary School Education to Prevent Drug Addiction and Implications for Iran por Kheradmand, Ali; Resident of Psychiatry, School of Medicine, Kerman University of Medical Sciences and Neuroscience Research Center,Zamani, Eshrat; Associate Professor, School of Education, University of Isfahan,Hedayati, Nassim; Resident, Department of Pediatric Dentistry, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran |
4 Comparative Evaluation of Psychiatric Disorders in Opium and Heroin Dependent Patients por Ghaffari Nejad, Alireza; Associate Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Ziaadini, Hassan; Associate Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Banazadeh, Nabi; Assistant Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences | 9 Rare Variant of Lycanthropy and Ecstasy por Nasirian, Mansoureh; Assistant Professor of Psychiatry, Kerman University of Medical Science,Banazadeh, Nabi; Resident of Neurology, School of Medicine, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine and Neuroscience Research Center Kerman University of Medical Sciences |
5 Frequency of Anabolic Steroids Abuse in Bodybuilder Athletes in Kerman City por Sepehri, Gholamreza; Professor of Pharmacology, Neuroscience and physiology Research Centers, Kerman University of Medical Sciences,,Mousavi Fard, Majid; General Practitioner, Kerman University of Medical Sciences,Sepehri, Ehsan; Medical student, Tehran University of Medical Sciences | 10 Psychosis following Tramadol Withdrawal por Rajabizadeh, Ghodratolah; Assistant Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine and Kerman Neurosciences Research Center, Kerman University of Medical Sciences,Nasirian, Mansoureh; Resident of Psychiatry, School of Medicine, Kerman University of Medical Sciences |