| Título: | Destructive Effects of Prenatal WIN 55212-2 Exposure on Central Nervous System of Neonatal Rats |
| Autores: |
Shabani, Mohammad; Assistant Professor, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran Divsalar, Kouros; Researcher, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran Janahmadi, Mahyar; Professor, Neuroscience Research Center, Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
| Fecha: | 2012-07-14 |
| Publicador: | Addicition & Health |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | Background: Cannabinoid, particularly hashish and WIN 55212-2 (WIN), consumption during embryonic period may affect fetal growth, and the development of motor functioning, memory and cognitive functions. Therefore, the present study aimed to evaluate the effects of WIN 55212-2 during embryonic period on behavioral responses, as well as tissue and memory changes among neonatal rats. Methods: WIN treated groups subcutaneously received daily doses of 0.5 or 1 mg/kg WIN suspended in 1% Tween-80-saline (1 mL/kg) from days 5 to 20 of pregnancy. The vehicle group received 1% Tween-80-saline from days 5 to 20 of pregnancy. Three, five and seven weeks after birth, the effects of maternal WIN consumption on infants' body weight, mortality, histological changes, motor functioning, and memory function were assessed. Findings: Prenatal WIN consumption was associated with atrophy of cerebellum cortex in granular and Purkinje cells layers. WIN treatment of pregnant rats produced a significant decrease in the rearing frequency of the offspring, but significantly increased the grooming frequency at 22, 36 and 50 days of age. During the acquisition trials, approach latencies were not significantly different between all groups of rats (50 days old). When the trial was repeated 24 hours and seven days later (retention trial), the avoidance latencies of the WIN-exposed group were significantly shorter than those of the control and vehicle animals. The mortality percent was increased significantly and litter size was decreased significantly in WIN (1 mg/kg) treated rats compared to the control, vehicle and WIN (0.5 mg/kg) treatment groups. Conclusion: These findings suggested that prenatal exposure to WIN probably induces long-term alterations in histological, motor functioning, and learning and memory parameters. Keywords: Hashish, WIN 55212-2, Cerebellum, Prenatal exposure, Memory, Motor functioning |
| Idioma: | Inglés |
1 Effects of Opium Smoking Cessation on the Nasopharyngeal Microbial Flora por Golshiri, Ali; Assistant Professor of Otorhinolaryngology and Chief of Moradi Hospital, Departments of Otorhinolaryngology, Moradi Hospital, Rafsanjan University of Medical Sciences,Mokhtaree, Mohammad Reza; Hospital Infection Control Nurse, Moradi Hospital, Rafsanjan University of Medical Sciences,Shabani, Ziba; Specialist in Infectious Disease, Ali-ibn- Abitalib Hospital, Rafsanjan University of Medical Sciences,Tabatabaee, Sayed Taghi; Assistant Professor of Pediatrics and Chief of School of Medicine, School of Medicine, Rafsanjan University of Medical Sciences,Rahnama, Amir; Pathologist, Vice Chancellor of Treatment, Rafsanjan University of Medical Sciences,Moradi, Mohammad; Assistant Professor of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences,Sayadi, Ahamad Reza; Ocupational Therapist, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences,Faezi, Hadi; Medical Student, School of Medicine, Rafsanjan University of Medical Sciences | 6 Epidemiologic Study on Drug Abuse among First and Second Grade High School Students in Kerman por Nakhaee, Nouzar; Associate Professor of Community Medicine, School of Medicine, Kerman Neuroscience Research,Ziaaddini, Hassan; Associate Professor of Psychiatry, Kerman University of Medical Sciences,Karimzadeh, Ali; General Physician, Kerman University of Medical Sciences, Kerman |
2 Relationship of Opium Dependency and Stroke por Hamzei Moqaddam, Akbar; Associate Professor of Neurology, School of Medicine, Kerman University of Medical Sciences,Ahmadi Musavi, Seyyed Mohammad Reza; Assistant Professor of Otorhinolaryngology, School of Medicine, Kerman University of Medical Sciences,Khademizadeh, Khatereh; Intern, Shefa Hospital, School of Medicine, Kerman University of Medical Sciences | 7 Prevalence of Cigarette Smoking in Schizophrenic Patients Compared to Other Hospital Admitted Psychiatric Patients por Ziaaddini, Hassan; Associate Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Vahabi, Mostafa; General Practitioner, School of Medicine, Kerman University of Medical Sciences |
3 Opiate Dependents’ Experiences of the Therapeutic Relationship in Methadone Centers; A Qualitative Study por Banazadeh, Nabi; Assistant Professor of Psychiatry, School of Medicine and Neuroscience Research Center, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine and Neuroscience Research Center, Kerman University of Medical Sciences,Abedi, Heidarali; Assistant Professor of Nursing Education, Khorasgan Azad University | 8 Exploit the Developed Countries Experiences of Primary School Education to Prevent Drug Addiction and Implications for Iran por Kheradmand, Ali; Resident of Psychiatry, School of Medicine, Kerman University of Medical Sciences and Neuroscience Research Center,Zamani, Eshrat; Associate Professor, School of Education, University of Isfahan,Hedayati, Nassim; Resident, Department of Pediatric Dentistry, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran |
4 Comparative Evaluation of Psychiatric Disorders in Opium and Heroin Dependent Patients por Ghaffari Nejad, Alireza; Associate Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Ziaadini, Hassan; Associate Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Banazadeh, Nabi; Assistant Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences | 9 Rare Variant of Lycanthropy and Ecstasy por Nasirian, Mansoureh; Assistant Professor of Psychiatry, Kerman University of Medical Science,Banazadeh, Nabi; Resident of Neurology, School of Medicine, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine and Neuroscience Research Center Kerman University of Medical Sciences |
5 Frequency of Anabolic Steroids Abuse in Bodybuilder Athletes in Kerman City por Sepehri, Gholamreza; Professor of Pharmacology, Neuroscience and physiology Research Centers, Kerman University of Medical Sciences,,Mousavi Fard, Majid; General Practitioner, Kerman University of Medical Sciences,Sepehri, Ehsan; Medical student, Tehran University of Medical Sciences | 10 Psychosis following Tramadol Withdrawal por Rajabizadeh, Ghodratolah; Assistant Professor of Psychiatry, School of Medicine, Kerman University of Medical Sciences,Kheradmand, Ali; Resident of Psychiatry, School of Medicine and Kerman Neurosciences Research Center, Kerman University of Medical Sciences,Nasirian, Mansoureh; Resident of Psychiatry, School of Medicine, Kerman University of Medical Sciences |