Título: Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.
Autores: BORSATO, D. M.
PRUDENTE, A. S.
DOLL-BOSCARDIN, P. M.
BORSATO, A. V.
LUZ, C. F. P.
MAIA, B. H. L. N. S.
CABRINI, D. A.
OTUKI, M. F.
MIGUEL, M. D.
FARAGO, P. V.
MIGUEL, O. G.
Fecha: 2014
2014-07-17
Publicador: Repositório Acesso Livre à Informação Científica da Embrapa (ALICE)
Fuente:
Tipo: Artigo em periódico indexado (ALICE)
Tema: Stingless bee
Pollen analysis
Mimosa scabrella
Monofloral honey
HPLC-UV-ESI-MS analysis
Phenolic compounds
Ear edema
Descripción: Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the highperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ? 5%. This extract decreased the myeloperoxidase activity in 75 ? 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ? 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.
2014
Idioma: en

Artículos similares:

Efeito da adubação nitrogenada e potássica de cobertura sobre a infestação de Diatraea saccharalis em sorgo sacarino. por CRUZ, S. C. B. da,VILELA, M.,MENDES, S. M.,SANTOS, F. C. dos,CARVALHO, E. A. R. de,SANTOS, A. E. dos
Percepção ambiental de produtores de milho relativa às plantas espontâneas na região Central de Minas Gerais. por MATRANGOLO, W. J. R.,OLIVEIRA, M. F. de,ALBERNAZ, W. M.,SILVA, I. H. S. da,MIRANDA, G. A.
Potencial alelopático de folhas de manga e jambolão sob a germinação e emergência de espécies cultivadas e nativas. por GATTI, A. B.,RONQUIM, C. C.,IMATOMI, M.,BERNARDO, V.,OLIVEIRA, A. V. de,PEREZ, S. C. J. G. de A.
10