| Título: | Phytochemical diversity in ashwagandha (Withania somnifera) |
| Autores: |
Sukanya, D. H. Lokesha, A.N. Datta, Gayatri Himabindu, K. |
| Fecha: | 2011-01-20 |
| Publicador: | Open access journal of medicinal and aromatic plants |
| Fuente: |
 |
| Tipo: | Peer-reviewd Article |
| Tema: | No aplica |
| Descripción: | (Abstract selected from presentation in National Conference on Biodiversity of Medicinal and Aromatic Plants: Collection, Characterization and Utilization, held at Anand, India during November 24-25, 2010) Ashwagandha (Withania somnifera Dunal) is an important commercial medicinal crop, which is considered as an alternate to Ginseng. It is a superior class herb with multiple benefits. Fruits, leaves and seeds of the plant have been used for ages in Ayurveda. The root has been used most frequently for therapeutic uses and is a constituent of over 200 formulations in Ayruvedha, Siddha and Unani medicines. Biologically active chemical constituents are withanolides with adaptogenic, aphrodisiac, diuretic, memory boosting and stress relieving properties. It is also protective towards arthritis, cartilage degradation, leprosy etc. Owing to its diverse therapeutic uses, there is renewed interest in phytochemistry of this crop. A large number of withanolides have been identified and different therapeutic activities are associated with different constituents viz., withaferine A associated with anti-inflammatory activity and is a safe radiosensitizer/chemotherapeutic agent, withanolide A and withanoside IV known for treatment of neurodegenerative diseases and Withanone for anti-cancer and antiaging activities, etc. The success of genetic improvement in this medicinal crop strongly depends on diversity of phytochemical content along with high potential for root yield. Though there are many reports on diversity for root yield and associated traits, systematic studies on chemical diversity are scarce and limited. Therefore efforts were made for systematic collection and evaluation of germplasm from diverse geographical locations in India. One hundred and eight selected accessions were assessed for chemical diversity. The accessions differed both quantitatively and qualitatively for withalonides estimated by HPLC method. The total withalonide content ranged from 0.066 to 0.588% on dry root basis in the accessions and as many as 13 accessions recorded more than 0.30%, which are considered as commercially viable. The analysis of withanolide profile in these accessions paved the way for identification of superior chemotypes, which recorded higher content of specific withalonides of therapeutic importance viz., withaferine A ( 0.345%), withalonide A(0.125%) and B (0.068%), withnone (0.100%), withanostromalide (0.048% ) and withanoside IV ( 0.227) and withanoside V (0.042) and also absence of specific withanolides such as waithanostromalide, withanone, withanoside V and withanolide B, thus indicating considerable diversity in the collection for phyto-chemicals. These chemotypes with high content of specific compounds are very important from pharmaceutical perspective. |
| Idioma: | No aplica |
1 Genetic diversity of Persian shallot (Allium hirtifolium) ecotypes based on morphological traits, allicin content and RAPD markers por Asili, Ali; Department of Plant Biotechnology, Faculty of Agriculture, Science and Research Campus, Azad Islamic University, Tehran, Iran,Behravan, Javad; Depatment of Biotechnology, Faculty of Pharmacy, University of Medical Science, P.O. Box,Naghavi, Mohammad Reza; University of Tehran,Asili, Javad; Depatment of Biotechnology, Faculty of Pharmacy, University of Medical Science, P.O. Box | 6 Micropropagation of Malaxis acuminata D. Don: A Rare Orchid of High Therapeutic Value por Kaur, Saranjeet; Plant tissue culture laboratory, Department of natural products,National institute of pharmaceutical education and research, Mohali,Punjab,Bhutani, K.K. |
2 Phenological attributes of Angelica glauca and A. archangelica expressed at two different climatic zones in Western Himalaya por Vashistha, Rajiv K.; HAPPRC,Butola, Jitendra S.; GBPIHED,Nautiyal, B.P.; HAMP,Nautiyal, M.C.; HAPPRC | 7 Integrated Nutrient Management on Growth, Yield, Quality and Economics of Bhumyamalaki (Phyllanthus amarus) – An Anti-jaundice Plant por R, Aruna Kumar,B, Raju,K, Umesha,G.R., Smitha,B.S., Sreeramu |
3 Essential Oil Composition of Menthol Mint (Mentha arvensis) and Peppermint (Mentha piperita) Cultivars at Different Stages of Plant Growth from Kumaon Region of Western Himalaya por Verma, R.S.; CIMAP, Resource Centre, Purara, Bageshwer, 263688, Uttarakhand, India,Rahman, L.; CIMAP, Lucknow,Verma, R.K.; CIMAP,Chauhan, A.; CIMAP,Yadav, A.K.; CIMAP,Singh, A.; CIMAP | 8 Reproductive Biology of Picrorhiza kurroa – a Critically Endangered High Value Temperate Medicinal Plant por raina, ravinder; Dr YSP University of Horticulture & forestry, Solan, HP,Mehra, Tara Singh; Deptt. of Forest products, Univ. of Horticulture & forestry, Solan,Chand, Romesh; Deptt. of Forest products, Univ. of Horticulture & forestry, Solan,Sharma, YashPal |
4 Oleanolic acid - an &alpha -Glucosidase inhibitory and antihyperglycemic active compound from the fruits of Sonneratia caseolaris por Tiwari, Ashok Kumar; Indian Institute of Chemical Technology, Hyderabad,Viswanadh, V.,Gowri, Ponnapalli Mangala,Ali, Amtul Zehra,Radhakrishnan, S.V.S.,Agawane, Sachin Bharat,Madhusudana, K.,Rao, Janaswamy Madhusudana | 9 |
5 Chemical composition of essential oil in dried fruits of Xylopia aethiopica from Sudan por Elhassan, Itmad Awad; Industrial Research and Consultancy Centre,Elamin, Elmubarak Elsiddig,Hussein Ayoub, Saad Mohamed | 10 Biodiversity of medicinal plants in north east India: their systematic utilisation por Shankar, Rama,Rawat, M.S. |