Título: RELATIONSHIP BETWEEN CELIAC DISEASE AND REFRACTORY IDIOPATHIC EPILEPSY IN CHILDREN
Autores: KARIMZADEH, Parvaneh; Assosiate Professor of Pediatric Neurology, Pediatric Neurology Research Center (PNRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran
KHAJEH, Ali; Assistant Professor of Pediatric Neurology, Research Center for Children and Adolescents Health (RCCAH), Zahedan University of Medical Sciences, Zahedan, Iran
TABARESTANI, Sepideh; Pediatric Neurologist,Pediatric Neurology Research Center, Tehran,Iran
AZARGASHB, Eznollah; Assistant professor, Shaid Beheshti University of Medical Sciences, Tehran, Iran
IMANZADEH, Farid; Pediatric Gastroenterologist, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AZARGASHB, Eznollah; Assistant professor, Shaid Beheshti University of Medical Sciences, Tehran, Iran
Fecha: 2011-02-16
Publicador: Iranian Journal of Child Neurology
Fuente:
Tipo: info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
original articles

Tema: No aplica
Descripción: ObjectiveEpilepsy occurs with a yearly incidence of 40 per 100,000 children, of which more than 25% are resistant to drug therapy. Epilepsy may occur in autoimmunediseases like lupus, celiac disease and myasthenia gravis. In this study, therelationship between celiac disease and refractory epilepsy was evaluated inchildren with idiopathic epilepsy.Material & MethodsHundred-fifty-five children (mean age, 6.7±3.3 years) with idiopathic andcryptogenic epilepsy referred to the neurology clinic were studied in two groups;drug controlled epilepsy (control, 82 patients) and refractory epilepsy groups(case, 73 patients). Both groups underwent serological tissue transglutaminaseantibody measurement by ELISA. In seropositive cases, small intestine biopsywas conducted. Data analysis was performed using student's t test and 2 test.ResultsSeven (0.04%) patients had celiac disease based on a positive tissuetransglutaminase antibody and three patients (0.01%) based on a positive biopsy.Three patients (2.4%) with drug controlled epilepsy (control group) and fivewith refractory epilepsy (case group) had seropositive celiac disease (p=0.255).In the biopsy survey of six seropositive patients, one patient (1.2%) in the drugcontrolled epilepsy and two patients (2.7%) in the refractory epilepsy group hadpositive biopsy for celiac disease (p = 0.604). One seropositive patient did notcooperate for biopsy.ConclusionIf the relationship between celiac disease and epilepsy, especially in casesof symptomatic or oligosymptomatic celiac is proved, using gluten freediet increases the ability to control epilepsy particularly in refractory cases.We suggest celiac disease survey is not required in patients with idiopathicepilepsy.Keywords: Epilepsy, Celiac disease, Children.
Idioma: Inglés

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