Título: Effect of growth hormone on muscle strength, tone and mobility of children with Prader-Willi syndrome
Autores: SALEHPOUR, Shadab; Assistant Professor of Pediatric Endocrinology and Fellowship of Bone and Inherited Metabolic Disorders,Shahid Beheshti University of Medical Sciences, Tehan ,Iran
Rohani, Farzaneh; Assistant Professor of Pediatric Endocrinology, Tehran University of Medical Sciences, Tehran, Iran
ARYANI, Omid; Senior Researcher, Molecular Genetics, Department of Medical Genetics, Special Medical Center, Tehran, Iran
HOUSHMAND, Massoud; Assistant Professor of Human Genetics, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
HASHEMINEZHAD, Farhad; Pulmonologist, Tehran, Iran
REZVANI KASHANI, Morteza; Pediatric Neurologist, Tehran, Iran
MAHVELATI SHAMSABADI, Farhad; Pediatric Neurologist, Tehran, Iran
POURNASIRI, Zahra; Professor of Pediatric Endocrinology, Tehran University of Medical Sciences, Tehran, Iran
Fecha: 2011-04-20
Publicador: Iranian Journal of Child Neurology
Fuente:
Tipo: info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
original articles

Tema: No aplica
Descripción: ObjectivePrader-Willi Syndrome (PWS) is a genetic syndrome presenting with severe hypotonia and decreased agility. Growth Hormone (GH), which is often used in these patients to treat short stature and obesity, seems improve hypotonia, physical strength, activity, and locomotor developmental ability. The aim ofthis study was to find the effects of growth hormone on agility and strength of these patients.Material & MethodsIn a prospective randomized controlled clinical trial in an out-patient pediatric endocrine clinic in Tehran, 21 PWS children (12 boys and 9 girls, 4 to 9 years old) were divided into either GH-treated or control groups and followed for two years. Agility run, sit ups, weight lifting, and inspiratory and expiratory strength were considered as the main outcome measures.ResultsAll the outcome measures of the GH treated group showed a significant improvement compared to the control group.ConclusionGH causes a significant improvement in agility and strength of PWS children.Key words: Preder-willi syndrome; PWS; growth hormone;agility; strength
Idioma: Inglés

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