| Título: | Initial clinical outcomes of intracoronary infusion of autologous progenitor cells in patients with acute myocardial infarction |
| Autores: |
Hashemi Jazi, Seyed Mohammad; Associate Professor, School of Medicine, Isfahan University Of Medical Sciences, Isfahan, Iran Nasr Esfahani, Mohammad Hossein; PhD, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, Avicenna Research Institute (ACECR), Tehran, Iran. Fesharaki, Mehrafarin; MSc, Department of Cell Sciences Research Center Medical Sciences, School of Medicine, Isfahan University of Medical Sciences Moulavi, Fariba; BSc, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, Avicenna Research Institute (ACECR), Tehran, Iran Gharipour, Mojgan; MSc Researcher, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. |
| Fecha: | 2012-05-12 |
| Publicador: | ARYA Atheroscler |
| Fuente: |
Ver documento |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | BACKGROUND: Myocardial infarction (MI) is an irreversible cardiomyocytes injury which begins after 15-20 minutes of coronary artery occlusion. The extent of infarction is modulated by a number of factors including collateral blood supplies, medications, and ischemic preconditioning. Although angioplasty and thrombolytic agents can relieve the cause of the infarction, the time from the occlusion onset to reperfusion determines the degree of irreversible myocardial injury. Experimental studies suggested that stem cells and progenitor cells derived from bone marrow can be used in the repair of cardiac tissue after acute MI. This study was designed to investigate the feasibility, safety and initial clinical outcome of intracoronary infusion of autologous progenitor cells in patients with acute MI.METHODS: Patients with a history of anterior MI and a left ventricular ejection fraction (LVEF) less than 35 % who were candidates for coronary angioplasty were randomly allocated in a 1:1 ratio to either control or bone marrow cell groups (each including 16 patients). Thallium scan and 17-segment echocardiography analysis for regional wall motion abnormality were performed before and 1 and 6 months after intracoronary infusion of bone marrow cells. The same tests were also conducted for the control group at identical time intervals. Categorical variables were compared by one way analysis of variance (ANOVA). Statistical significance was assumed at a value of P < 0.05.RESULTS: LVEF in the case and control groups increased to 39.37 ± 24.7% and 31.00 ± 1.87%, respectively (P = 0.069 and 0.1, respectively). Wall motion abnormality index (WMAI) decreased insignificantly in both groups. Perfusion defect scores (PDSs) decreased significantly in the case group.CONCLUSION: In this study, autologous mesenchymal stem cell transplantation by intracoronary catheter during angioplasty in patients with a history of severe LV dysfunction caused mild increases in LVEF.Keywords: Myocardial Infarction Left Ventricular Failure, Stem Cell. |
| Idioma: | Inglés |
1 COMPARING THE EFFECTS OF LOVASTATIN AND CORNUS MAS FRUIT ON FIBRINOGEN LEVEL IN HYPERCHOLESTEROLEMIC RABBITS por Asgary, Sedigheh; Associate Professor of Pharmacognosy, Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan,Rafieian-Kopaei, Mahmoud; Professor of Pharmacology, Shahrekord Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Sharekord,Adelnia, Azadeh; MSc, Animal Physiology, Department of Biology, University of Payam-Noor. Isfahan,Kazemi, Somayeh; MSc, Animal Physiology, Department of Biology, The University of Isfahan, Isfahan,Shamsi, Fatemeh; MSc, Animal Physiology, Department of Biology, University of Payam-Noor. Isfahan | 6 IS THERE ANY RELATIONSHIP BETWEEN C-REACTIVE PROTEIN LEV-EL AND COMPLEX CORONARY PLAQUES IN PATIENTS WITH UNSTABLE ANGINA? por Sadeghi, Masoumeh; Associate Professor, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,,Pourmoghaddas, Masoud; Professor, Isfahan University of Medical Sciences, Isfahan,Tavasoli, Aliakbar; Associate Professor, Isfahan University of Medical Sciences, Isfahan,Roohafza, Hamidreza; Psychiatrist, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan |
2 THE RELATIONSHIP BETWEEN ANKLE-BRACHIAL INDEX AND NUM-BER OF INVOLVED CORONARIES IN PATIENTS WITH STABLE ANGINA por Sadeghi, Masoumeh; Associated Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,,Tavasoli, AliAkbar; Associated Professor of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan,Roohafza, Hamidreza; Psychiatrist of Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Sarrafzadegan, Nizal; Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan | 7 DELAY AND ITS RELATED FACTORS IN SEEKING TREATMENT IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION por Taghaddosi, Mohsen; Department of Medical-Surgical Nursing, Kashan University of Medical Sciences, Kashan,Dianati, Mansour; Medical Student, Kashan University of Medical Sciences, Kashan,Fath Gharib Bidgoli, Javad; Department of Medical Technology, Kashan University of Medical Sciences, Kashan,Bahonaran, Javad; Department of Medical Technology, Kashan University of Medical Sciences, Kashan |
3 LIVER-PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF ALLIUM HIRTIFOLIUM BOISS. IN RATS WITH ALLOXAN-INDUCED DI-ABETES MELLITUS por Kazemi, Somayeh; Department of Biology, School of Sciences, The University of Isfahan and Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Asgary, Sedigheh; Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan,Moshtaghian, Jamal; Department of Biology, School of Sciences, The University of Isfahan, Isfahan,Rafieian, Mahmoud; Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord,Adelnia, Azadeh; Department of Biology, School of Science, Isfahan Payam-e-Noor University, Isfahan,Shamsi, Fatemeh; Department of Biology, School of Science, Isfahan Payam-e-Noor University, Isfahan | 8 PULMONIC VALVE ENDOCARDITIS WITH PULMONARY ARTERY ENDARTERITIS IN A YOUNG MAN WITH CONGENITAL VENTRAL SEPTAL DEFECT por Fazlinezhad, Afsoon; Associate Professor of Cardiology, Department of Echocardiography, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad,Fallah, Azadeh; Resident of Cardiology, Department of Cardiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad,Esfahanizadeh, Jamil; Assistant Professor of Cardiac Surgery, Department of Cardiac Surgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, |
4 EFFECT OF HYDROGENATED, LIQUID AND GHEE OILS ON SERUM LI-PIDS PROFILE por Mohammadifard, Noushin; MSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Nazem, Masoud; Associate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan,Naderi, Gholam-Ali; Associate Professor, Department of Basic Sciences, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Saghafian, Faezeh; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Sajjadi, Firoozeh; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Maghroon, Maryam; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Bahonar, Ahmad; MD, MPH, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Alikhasi, Hasan; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Nouri, Fatemeh; Biostatistics Unit, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan | 9 EFFECT OF DIFFERENT PHYSICAL ACTIVITY TRAINING METHODS ON OVERWEIGHT ADOLESCENTS por Ghatrehsamani, Shohreh; Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Khavarian, Noushin; Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Beizaei, Maryam; Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Ramedan, Reza; Senior Expert, Isfahan Sport Training Organization, Isfahan,Poursafa, Parinaz; Senior Expert, Isfahan Sport Training Organization, Isfahan,Kelishadi, Roya; Associate Professor of Pediatrics, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan |
5 THE ASSOCIATION OF GENERAL AND CENTRAL OBESITY WITH MA-JOR DIETARY PATTERNS IN ADULT WOMEN LIVING IN TEHRAN, IRAN por Rezazadeh, Arezoo; MSc, Department of Community Nutrition, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran,Rashidkhani, Bahram; PhD, Department of Community Nutrition, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran | 10 EVALUATION OF LEPTIN AND ADIPONECTIN LEVELS IN PATIENTS WITH STABLE ANGINA PECTORIS por Mozafari, Masoud; Cardiology Resident, Isfahan University of Medical Sciences, Isfahan,Sadeghi, Masoumeh; Associate Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Sanei, Hamid; Associate Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan,Ramezani, Mohammad Arash; Community Medicine Specialist, Isfahan Cardiovascular Research Center, Isfahan,Golabchi, Allahyar; Cardiology Resident, Isfahan University of Medical Sciences, Isfahan,Sarrafzadegan, Nizal; Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences Isfahan |