| Título: | EFFECT OF AN ANTI-INFLAMMATORY DRUG (PIROXICAM) ON SOME BIOCHEMICAL FACTORS AND DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS |
| Autores: |
Asgary, Sedigheh; Associate Professor (Ph.D), Isfahan Cardiovascular Research Center a WHO Collaborating Center For Research And Training In Cardiovascular Diseases Control, Prevention For Cardiac Patients in EMRO Naderi, Gholam-Ali; Ph.D(2), Dashti, Gholam-Reza; Ph.D(3), Paknahad, Zamzam; Ph.D |
| Fecha: | 2010-12-21 |
| Publicador: | ARYA Atheroscler |
| Fuente: |
Ver documento |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | ABSTRACT Objective: To investigate the effect of an anti-inflammatory drug (Piroxicam) on the development of fatty streak in rabbits. Methods: Male rabbits were fed with four types of regimen: a) normal rabbit chow, b) 1% cholesterol diet c) cholesterol diet plus Piroxicam, d) normal rabbit chow plus Piroxicam. After 12 weeks, the animals were sacrificed and the aorta, as well as the right and left branches of the coronary artery were dissected, and histological processing was carried out. Samples were observed under light microscope with different magnifications. Some biochemical tests were measured before and after the treatment. Results: A significant difference was found between the two groups receiving Piroxicam-supplemented diet and the two others (p<0.05) in respect of the mean grade of fatty streaks in the right and left coronary arteries, however, progression of the lesion in aorta was not statistically significant. Conclusion: Piroxicam was found to reduce C-reactive protein (CRP), triglyceride (TG) and LDL-C; it also led to an increase in antioxidant capacity and HDL-C. It is suggested that the anti-inflammatory drug, Piroxicam, has beneficial effects in preventing the development of fatty streaks. Key words: Fatty streak, piroxicam, rabbit, inflammation. |
| Idioma: | Inglés |
1 COMPARING THE EFFECTS OF LOVASTATIN AND CORNUS MAS FRUIT ON FIBRINOGEN LEVEL IN HYPERCHOLESTEROLEMIC RABBITS por Asgary, Sedigheh; Associate Professor of Pharmacognosy, Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan,Rafieian-Kopaei, Mahmoud; Professor of Pharmacology, Shahrekord Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Sharekord,Adelnia, Azadeh; MSc, Animal Physiology, Department of Biology, University of Payam-Noor. Isfahan,Kazemi, Somayeh; MSc, Animal Physiology, Department of Biology, The University of Isfahan, Isfahan,Shamsi, Fatemeh; MSc, Animal Physiology, Department of Biology, University of Payam-Noor. Isfahan | 6 IS THERE ANY RELATIONSHIP BETWEEN C-REACTIVE PROTEIN LEV-EL AND COMPLEX CORONARY PLAQUES IN PATIENTS WITH UNSTABLE ANGINA? por Sadeghi, Masoumeh; Associate Professor, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,,Pourmoghaddas, Masoud; Professor, Isfahan University of Medical Sciences, Isfahan,Tavasoli, Aliakbar; Associate Professor, Isfahan University of Medical Sciences, Isfahan,Roohafza, Hamidreza; Psychiatrist, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan |
2 THE RELATIONSHIP BETWEEN ANKLE-BRACHIAL INDEX AND NUM-BER OF INVOLVED CORONARIES IN PATIENTS WITH STABLE ANGINA por Sadeghi, Masoumeh; Associated Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,,Tavasoli, AliAkbar; Associated Professor of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan,Roohafza, Hamidreza; Psychiatrist of Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Sarrafzadegan, Nizal; Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan | 7 DELAY AND ITS RELATED FACTORS IN SEEKING TREATMENT IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION por Taghaddosi, Mohsen; Department of Medical-Surgical Nursing, Kashan University of Medical Sciences, Kashan,Dianati, Mansour; Medical Student, Kashan University of Medical Sciences, Kashan,Fath Gharib Bidgoli, Javad; Department of Medical Technology, Kashan University of Medical Sciences, Kashan,Bahonaran, Javad; Department of Medical Technology, Kashan University of Medical Sciences, Kashan |
3 LIVER-PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF ALLIUM HIRTIFOLIUM BOISS. IN RATS WITH ALLOXAN-INDUCED DI-ABETES MELLITUS por Kazemi, Somayeh; Department of Biology, School of Sciences, The University of Isfahan and Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Asgary, Sedigheh; Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan,Moshtaghian, Jamal; Department of Biology, School of Sciences, The University of Isfahan, Isfahan,Rafieian, Mahmoud; Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord,Adelnia, Azadeh; Department of Biology, School of Science, Isfahan Payam-e-Noor University, Isfahan,Shamsi, Fatemeh; Department of Biology, School of Science, Isfahan Payam-e-Noor University, Isfahan | 8 PULMONIC VALVE ENDOCARDITIS WITH PULMONARY ARTERY ENDARTERITIS IN A YOUNG MAN WITH CONGENITAL VENTRAL SEPTAL DEFECT por Fazlinezhad, Afsoon; Associate Professor of Cardiology, Department of Echocardiography, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad,Fallah, Azadeh; Resident of Cardiology, Department of Cardiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad,Esfahanizadeh, Jamil; Assistant Professor of Cardiac Surgery, Department of Cardiac Surgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, |
4 EFFECT OF HYDROGENATED, LIQUID AND GHEE OILS ON SERUM LI-PIDS PROFILE por Mohammadifard, Noushin; MSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Nazem, Masoud; Associate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan,Naderi, Gholam-Ali; Associate Professor, Department of Basic Sciences, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Saghafian, Faezeh; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Sajjadi, Firoozeh; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Maghroon, Maryam; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Bahonar, Ahmad; MD, MPH, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Alikhasi, Hasan; BSc, Department of Nutrition, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Nouri, Fatemeh; Biostatistics Unit, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan | 9 EFFECT OF DIFFERENT PHYSICAL ACTIVITY TRAINING METHODS ON OVERWEIGHT ADOLESCENTS por Ghatrehsamani, Shohreh; Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Khavarian, Noushin; Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Beizaei, Maryam; Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Ramedan, Reza; Senior Expert, Isfahan Sport Training Organization, Isfahan,Poursafa, Parinaz; Senior Expert, Isfahan Sport Training Organization, Isfahan,Kelishadi, Roya; Associate Professor of Pediatrics, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan |
5 THE ASSOCIATION OF GENERAL AND CENTRAL OBESITY WITH MA-JOR DIETARY PATTERNS IN ADULT WOMEN LIVING IN TEHRAN, IRAN por Rezazadeh, Arezoo; MSc, Department of Community Nutrition, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran,Rashidkhani, Bahram; PhD, Department of Community Nutrition, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran | 10 EVALUATION OF LEPTIN AND ADIPONECTIN LEVELS IN PATIENTS WITH STABLE ANGINA PECTORIS por Mozafari, Masoud; Cardiology Resident, Isfahan University of Medical Sciences, Isfahan,Sadeghi, Masoumeh; Associate Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan,Sanei, Hamid; Associate Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan,Ramezani, Mohammad Arash; Community Medicine Specialist, Isfahan Cardiovascular Research Center, Isfahan,Golabchi, Allahyar; Cardiology Resident, Isfahan University of Medical Sciences, Isfahan,Sarrafzadegan, Nizal; Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences Isfahan |