| Título: | DO L-ARGININE AND L-NAME ALTER CORONARY VASCULAR AND AORTIC ENDOTHELIAL PERMEABILITY IN NORMAL- AND HIGH-CHOLESTEROL-FED RATS? |
| Autores: |
Khazaei, Majid; MD, PhD, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. Haghparast, Elham; MSc. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. Afshar, Mohammad; PhD. Department of Anatomy, Birjand university of medical sciences, Birjand, Iran. |
| Fecha: | 2010-12-08 |
| Publicador: | ARYA Atheroscler |
| Fuente: |
Ver documento |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | Abstract INTRODUCTION: The objective of this study was to evaluate the effect of L-arginine (L-Arg) and L-NAME on coronary vascular and aortic endothelial permeability in normocholesterolemic (NC) and hypercholesterolemic (HC) rats. METHODS: Forty-eight male rats were divided into NC and HC groups and each group was divided into L-Arginine-treated, L-NAME-treated and control subgroups. L-Arg (2.25%) and L-NAME (0.75 mg/ml) were dissolved in drinking water and control groups received tap water. After 8 weeks, endothelial permeability was assessed by using the Evans Blue (EB) dye method. RESULTS: Aortic endothelial permeability was significantly higher in HC group compared to NC group (15.1±0.7 vs. 7.7±0.8 µgEB/g tissue, respectively; P<0.05). L-Arg and L-NAME treatment decreased aortic endothelial permeability in HC animals (L-Arg: 8.4±0.4 & L-NAME: 10.8±0.6 vs. 15.1±0.7 µgEB/g tissue, respectively; P<0.05). There was no significant difference in endothelial permeability in coronary circulation between HC and NC groups and L-Arg and L-NAME did not alter endothelial permeability. CONCLUSION: It seems that L-Arg and L-NAME have different effects on endothelial permeability based on physiological and pathological conditions and type of vessel. Keywords: L-Arginine, L-NAME, nitric oxide, endothelium, permeability. |
| Idioma: | Inglés |
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