| Título: | HISTOLOGICAL GRADING IN DUCTAL CARCINOMA IN SITU OF THE BREAST |
| Autores: |
Xu, Wei-ling Zhu, Xiong-zeng Zhang, Ting-qiu Tu, Xiao-yu Shi, Da-ren |
| Fecha: | 2013-02-22 |
| Publicador: | Chinese Journal of Cancer Research |
| Fuente: |
Ver documento |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | Objective: To study the significance of histological grading as a prognostic factor in ductal carcinoma in situ of the breast. Methods: According to the Van Nuy's classification, 32 cases of ductal carcinoma in silu (DCIS) of the breast were divided into three groups. Results: Low grade (well differentiated, low grade DCIS) 12 patients (37.5%); Intermediate grade, 9 patients (28.1%); High grade (poorly differentiated DCIS) 11 patients (34.4%). Among the high grade DCIS, the histologic subtypes were comedo (9 patients), micropapillary (1 patient) and solid (1 patient). The positive expression of c.erbB-2, p53 and MIB- 1 in high grade DCIS was higher than that in intermediate and low grade DCIS. The difference between high grade and low grade DCIS was significant (P<0.05). The expression of ER in high grade DCIS was lower than that in intermediate and low grade DCIS. Conclusions: Histological grading of breast ductal carcinoma in situ may be a good prognostic factor. |
| Idioma: | Inglés |