| Título: | Protein Profiles Correlated with Recurrence of Early Stage Non-Small Cell Lung Cancer |
| Autores: |
Lu, Zhe-ming Hong, Shao-lin |
| Fecha: | 2010-03-30 |
| Publicador: | Chinese Journal of Cancer Research |
| Fuente: |
Ver documento |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | Objective: To elucidate protein markers that differentiate stage I non-small cell lung cancer (NSCLC) that subsequently develop metastatic disease to those that do not develop metastasis by protein expression profiles. Methods: Matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and two dimensional difference gel electrophoresis (2D-DIGE) platforms were used to separate proteins in whole tumor specimens. Quantitating mRNA expression was used for validation. Results: Twelve proteins were identified as expressed differentially between two groups from protein expression platforms. But from gene expression platform no marker could distinguish patients with recurrent vs. nonrecurrent disease. Conclusion: Analysis of multiple protein markers may be more informative to predict prognosis of early stage lung cancer. |
| Idioma: | Inglés |