| Título: | Treatment with mebendazole is not associated with distal migration of adult Angiostrongylus costaricensis in the murine experimental infection |
| Autores: |
Mentz, Marcia Bohrer Teixeira, Carlos Graeff Garrido, Cinara Tentardini |
| Fecha: |
2010-06-01 2004 |
| Publicador: | |
| Fuente: |
Ver documento |
| Tipo: |
Artigo de periódico Nacional |
| Tema: |
Angiostrongylus costaricencis Parasitologia Adult stage Migration Mebendazole |
| Descripción: | Abdominal angiostrongyliasis is a zoonotic infection produced by a metastrongylid intra-arterial nematode, Angiostrongylus costaricensis. Human accidental infection may result in abdominal lesions and treatment with anti-helminthics is contra-indicated because of potential higher morbidity with excitement or death of worms inside vessels. To evaluate the effect of mebendazole on localization of the worms, male Swiss mice, 5 week-old, were infected with 10 third stage larvae per animal. Twelve infected mice were treated with oral mebendazol, at 5 mg/kg/day, for 5 consecutive days, begining 22 days after inoculation. As control groups, 12 infected but non-treated mice and other 12 non-infected and non-treated mice were studied. The findings at necropsy were, respectively for the treated (T) and control (C) groups: 92% and 80% of the worms were inside the cecal mesenteric arterial branch; 8% and 10% were located inside the aorta. Only in the group C some worms (10%) were found inside the portal vein or splenic artery. These data indicate that treatment with mebendazole does not lead to distal or ectopic migration of A. costaricensis worms. |
| Idioma: | Inglés |
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3 | 8 O clítico acusativo na redação escolar por Dutra, Líria Romero |
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