| Título: | Heterotopic transplantation of glycerin-preserved trachea : effect of respiratory epithelium desquamation on acute rejection |
| Autores: |
Saueressig, Mauricio Guidi Edelweiss, Maria Isabel Albano Souza, Fabiano H. Moreschi, Alexandre Heitor Savegnago, Fabrício L. Macedo Neto, Amarilio Vieira de |
| Fecha: |
2010-04-24 2005 |
| Publicador: | |
| Fuente: |
Ver documento |
| Tipo: |
Artigo de periódico Nacional |
| Tema: |
Graft rejection Rejeição de enxerto Traquéia : Transplante Trachea Transplantation Tranplante Glicerol Glycerol Mucosa respiratória Respiratory mucosa |
| Descripción: | An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups: autograft (N = 21), fresh allograft (N = 18) and glycerin-preserved allograft (N = 22). Two segments from different groups were implanted into the greater omentum of dogs (N = 31). After 28 days, the segments were harvested and analyzed for mononuclear infiltration score and for the presence of respiratory epithelium. The fresh allograft group presented the highest score for mononuclear infiltration (1.78 ± 0.43, P ≤ 0.001) when compared to the autograft and glycerinpreserved allograft groups. In contrast to the regenerated epithelium observed in autograft segments, all fresh allografts and glycerinpreserved allografts had desquamation of the respiratory mucosa. The low antigenicity observed in glycerin segments was probably the result of denudation of the respiratory epithelium and perhaps due to the decrease of major histocompatibility complex class II antigens. |
| Idioma: | Portugués |
1 | 6 |
2 A vida em separado : estudo de um condomínio fechado de Porto Alegre por Quadros, Caroline Souza de | 7 |
3 | 8 O clítico acusativo na redação escolar por Dutra, Líria Romero |
4 "O passado está prenhe do futuro" : a escrita da história no Instituto Histórico e Geográfico do Rio Grande do Sul (1920-30) por Silveira, Daniela Oliveira | 9 Superfície de imagens : o tema do olhar em Borges e em Cortázar por Botelho, José Francisco Hillal Tavares de Junqueira |
5 | 10 |