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Título: Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.
Autores: Rose, Christopher F.
Butterworth, Roger F.
Zayed, Joseph
Normandin, Louise
Todd, Kathryn
Michalak, Adrianna
Spahr, Laurent
Huet, Pierre-Michel
Pomier-Layrargues, Gilles
Fecha: 2013-04-23
2013-04-23
1999
Publicador:
Fuente: Ver documento
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Tipo: Article
Tema: Anastomose chirurgicale portosystémique
Basal ganglia
Cirrhosis
Encéphalopathie hépatique
Fibrose
Hepatic encephalopathy
Imagerie par résonance magnétique
Manganese
Manganèse
magnetic resonance imaging
Noyaux gris centraux
Portal-systemic shunting
Descripción: BACKGROUND & AIMS: Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobiliary dysfunction. METHODS: Mn concentrations were measured in (1) brain samples from basal ganglia structures (pallidum, putamen, caudate nucleus) and cerebral cortical structures (frontal, occipital cortex) obtained at autopsy from 12 cirrhotic patients who died in hepatic coma and from 12 matched controls; and from (2) brain samples (caudate/putamen, globus pallidus, frontal cortex) from groups (n = 8) of rats either with end-to-side portacaval anastomosis, with biliary cirrhosis, or with fulminant hepatic failure as well as from sham-operated and normal rats. RESULTS: Mn content was significantly increased in frontal cortex (by 38\%), occipital cortex (by 55\%), pallidum (by 186\%), putamen (by 66\%), and caudate (by 54\%) of cirrhotic patients compared with controls. Brain Mn content did not correlate with patient age, etiology of cirrhosis, or history of chronic hepatic encephalopathy. In cirrhotic and portacaval-shunted rats, Mn content was increased in pallidum (by 27\% and 57\%, respectively) and in caudate/putamen (by 57\% and 67\%, respectively) compared with control groups. Mn concentration in pallidum was significantly higher in portacaval-shunted rats than in cirrhotic rats. No significant changes in brain Mn concentrations were observed in rats with acute liver failure. CONCLUSIONS: These findings suggest that brain Mn deposition results both from portal-systemic shunting and from liver dysfunction.
Idioma: Inglés