| Título: | Early steroid withdrawal in pediatric renal transplant on newer immunosuppressive drugs |
| Autores: |
Delucchi, Angela Valenzuela, Marcela Ferrario, Mario Lillo, Ana María Guerrero, José Luis Rodríguez, Eugenio Cano, Francisco Cavada, Gabriel Godoy L., Jorge Rodríguez, Jorge González, C. Gloria Buckel, Erwin Contreras, Luis |
| Fecha: |
2010-07-30 2007 |
| Publicador: | Blackwell |
| Fuente: | |
| Tipo: | Artículo de Revista |
| Tema: |
immunosuppressive treatment steroid withdrawal pediatric kidney transplantation |
| Descripción: | Steroids have been a cornerstone in renal transplant immu- nosuppression. New immunosuppressive drugs have led to protocols using early steroid withdrawal or complete avoidance. A prospective protocol in 23 pediatric renal transplant (ages 2–14 yr) who received decreasing steroid doses stopping at day 7 post-Tx, FK, and MMF were compared with a CsA, AZT, historically matched steroid-based control group. Basiliximab was used in two doses. Anthropometric, biochemical variables, AR rates, and CMV infection were evaluated and compared using Student s t-test and regression analysis. A better growth pattern 2 was seen in steroid withdrawal group. GFR rate and serum glucose were similar in both groups. Total serum cholesterol levels were signi- ficantly lower in steroid withdrawal group. The incidence of AR at 12 months was 4.3% in steroid withdrawal group vs. 8.6% in steroid- based group (p = ns). No difference in CMV infection was observed. Hemoglobin levels were low during the first months in both groups; reached normal values after six months. SBP became higher at 12 months in steroid-based group. Patient and graft survival was 98% in both groups at one-yr post-transplant. Early steroid withdrawal was efficacious, safe, and did not increase risk of rejection, preserving optimal growth, renal function, and reducing cardiovascular risk fac- tors. |
| Idioma: | Inglés |