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Título: Group electrophilicity as a model of nucleofugality in nucleophilic substitution reactions
Autores: Campodónico, Paola R.
Aizman, Arie
Contreras Ramos, Renato
Fecha: 2008-12-15
2008-12-15
2006-05-10
Publicador: ELSEVIER
Fuente: Ver documento
Tipo: Artículo de Revista
Tema: STRUCTURE-REACTIVITY CORRELATIONS
4-NITROPHENYL THIONOCARBONATES
2,4-DINITROPHENYL CARBONATES
ELIMINATION-REACTIONS
METHYL 4-NITROPHENYL
CONCERTED MECHANISM
ALICYCLIC AMINES
LEAVING GROUPS
AMINOLYSIS
KINETICS
Descripción: We propose and test an empirical nucleofugality index to rank the leaving group ability of a series of molecular fragments present in nucleophilic substitution reactions of carbonyl and thiocarbonyl derivatives. The nucleofugality index is defined as the group electrophilicity of the leaving group embedded in the substrate that undergoes the nucleophilic attack. The reliability and usefulness of this new reactivity index is tested against experimental kinetic data.
Idioma: Inglés
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