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Título: Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula
Autores: Birch, Eileen E.
Garfield, Sharon
Castañeda, Yolanda
Hughbanks Wheaton, Dianna
Uauy, Ricardo
Hoffman, Dennis
Fecha: 2008-05-08
2008-05-08
2007
Publicador:
Fuente: Ver documento
Tipo: Artículo de Revista
Tema: long-chain polyunsaturated
fatty acids
visual acuity
IQ
infant
infant formula
preschool child
TERM INFANTS
DOCOSAHEXAENOIC ACID
AMBLYOPIA TREATMENT
TESTING PROTOCOL/
HUMAN BRAIN
GROWTH
PHOSPHOGLYCERIDES
ESSENTIALITY
METABOLISM
RETINA
Descripción: Publicación ISI
Email : ebirch@retinafoundation.org
Background: While there is a large body of data on the effects of long-chain polyunsaturated fatty acid supplementation of infant formula on visual and cognitive maturation during infancy, longterm visual and cognitive outcome data from randomized trials are scarce. Aim: To evaluate docosahexaenoic acid (DHA) and arachidonic acid (ARA)-supplementation of infant formula on visual and cognitive outcomes at 4 years of age. Methods: Fifty-two of 79 healthy term infants who were enrolled in a single-center, double-blind, randomized clinical trial of DHA and ARA supplementation of infant formula were available for follow-up at 4 years of age. In addition, 32 breast-fed infants served as a "gold standard". Outcome measures were visual acuity and the Wechsler Preschool and Primary Scale of Intelligence - Revised. Results: At 4 years, the control formula group had poorer visual acuity than the breast-fed group; the DHA- and DHA+ARA-supplemented groups did not differ significantly from the breast-fed group. The control formula and DHA-supplemented groups had Verbal IQ scores poorer than the breast-fed group. Conclusion: DHA and ARA-supplementation of infant formula supports visual acuity and IQ maturation similar to that of breast-fed infants. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
Idioma: Inglés
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