| Título: | Unexpected diastereotopic behaviour in the H-1 NMR spectrum of 1,4-dihydropyridine derivatives triggered by chiral and prochiral centres |
| Autores: |
Da Silva, Jaqueline Barría, Claudio Jullian, Carolina Navarrete, Patricio Nuñez, Luis Squella, J. A. |
| Fecha: |
2007-05-18 2007-05-18 2005-01 |
| Publicador: | SOC BRASILEIRA QUIMICA |
| Fuente: |
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| Tipo: | Artículo de Revista |
| Tema: |
HANTZSCH 1,4-DIHYDROPYRIDINES MICROWAVE IRRADIATION 4-ISOXAZOLYL-1,4-DIHYDROPYRIDINES |
| Descripción: | 1,4-dihydropyridine derivatives constitute an important pharmacological group for the treatment of cardiovascular diseases. We have synthesised a series 4-(5'-nitro-2'-furyl)-1,4-dihydropyridine derivatives, which were characterised by H-1-NMR. We have found that carboethoxy groups at the C-3 and C-5 on the 1,4-dihydropyridine ring show a much more complex signal in the H-1 NMR spectra, either when C-4 is a pseudo-prochiral or a chiral centre. |
| Idioma: | Inglés |