| Título: | Mechanisms for induction of acquired host immunity by neutrophil peptide defensins |
| Autores: |
Lillard, James W. Boyaka, Prosper N. Chertov, Oleg Oppenheim, Joost J. McGhee, Jerry R. |
| Fecha: | 1999-01-19 |
| Publicador: | The National Academy of Sciences |
| Fuente: |
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| Tipo: | Text |
| Tema: | Biological Sciences |
| Descripción: | Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus ovalbumin (OVA) enhanced OVA-specific serum IgG antibody (Ab) responses. However, OVA-specific IgA Abs were not induced in mucosal secretions or in serum. CD4+ T cells of intranasally immunized mice displayed higher OVA-specific proliferative responses and elevated production of interferon γ, interleukin (IL) 5, IL-6, and IL-10 when compared with control groups receiving OVA alone. In vitro, HNPs also enhanced both proliferative responses and T helper (Th) cytokine secretion profiles of CD3ɛ-stimulated spleen- and Peyer’s patch-derived naive CD4+ T cells. HNPs modulated the expression of costimulatory molecules by lipopolysaccharide- or CD3ɛ-stimulated splenic and Peyer’s patch B or T cell populations, respectively. These studies show that defensins enhance systemic IgG, but not IgA, Ab responses through help provided by CD4+ Th1- and Th2-type cytokines and foster B and T cell interactions to link innate immunity with the adaptive immune system. |
| Idioma: | en |