| Título: | Invitro Photo-Controlled Drug Release System Based on Amphiphilic Linear-Dendritic Diblock Copolymers; Self-Assembly Behavior and Application as Nanocarrier |
| Autores: |
Namazi, Hassan; University of Tabriz Jafarirad, Saeed |
| Fecha: | 2011-05-08 |
| Publicador: |
Journal of Pharmacy & Pharmaceutical Sciences Journal of Pharmacy & Pharmaceutical Sciences |
| Fuente: |
Ver documento |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | Purpose. A simple type of photoresponsive amphiphilic linear-dendritic diblock copolymer has been synthesized and investigated for its ability to act as a drug carrier. These structures contain hydrophilic polyethylene oxide monomethyl ether (PEOM) as hydrophilic block and carbosiloxane dendritic branches as hydrophobic block grafted by two and six Magneson II as azo chromophore, PEOM-Azo, 2 and PEOM-Azo, 6 respectively. Self-assembling of the amphiphilic macromolecules of PEOM-Azo, 2 and PEOM-Azo, 6, briefly were represented as PEOM-Azo [2, 6], leads to the formation of their micellar aggregates in aqueous media. Method. Their micellar properties such as critical micelle concentration (CMC), aggregation number and thereby total numbers of azo-groups in each micellar aggregates were determined. Also, they were characterized by TEM, SEM and DLS. Results. The unloaded aggregates examined under UV light (366 nm), which were observed to be smaller than 300 nm. The release patterns of the encapsulated drug molecule from these aggregates were investigated as regulated by the PEOM-Azo [2, 6] systems in trans and cis forms. Conclusion. A comparison of the release behavior of the loaded PEOM-Azo [2, 6] systems indicated that the release rate of the encapsulated active molecules from the carriers was slower when the azo moieties were in trans form as compared to that the azo in the cis form. The in vitro release behavior of drug from these polymeric systems represents potential of the carriers for controlled drug delivery. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page. |
| Idioma: | Inglés |
1 The Impact of Electronic Prescribing on the Professionalization of Community Pharmacists: A Qualitative Study of Pharmacists’ Perception por Motulsky, Aude; Université de Montréal,Winslade, Nancy; McGill University,Tamblyn, Robyn; McGill University,Sicotte, Claude; Université de Montréal | 6 Effect of Inflammation on Molecular Targets and Drug Transporters por Hanafy, Sherif; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada,El-Kadi, Ayman O.S.,Jamali, Fakhreddin; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada |
2 Statins Against Drug-Induced Nephrotoxicity por Dashti-Khavidaki, Simin; Tehran University of Medical Sciences,Moghaddas, Azadeh; Tehran University of Medical Sciences,,Heydari, Behrooz; Tehran University of Medical Sciences,,Khalili, Hossein; Tehran University of Medical Sciences,lessan-Pezeshki, Mahboob; Tehran University of Medical Sciences,,Lessan-Pezeshki, Mahbooh; Tehran University of Medical Sciences | 7 |
3 Hepatotoxic Botanicals - An Evidence-based Systematic Review por Abdualmjid, Reem J; University of Alberta,Sergi, Consolato; University of Alberta | 8 |
4 The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion por Ogura, Jiro,Terada, Yusuke,Tsujimoto, Takashi,Koizumi, Takahiro,Kuwayama, Kaori,Maruyama, Hajime,Fujikawa, Asuka,Takaya, Atsushi,Kobayashi, Masaki,Itagaki, Shirou,Takahashi, Natsuko,Hirano, Takeshi,Yamaguchi, Hiroaki,Iseki, Ken | 9 Functional Food and Nutraceutical Registration Processes in Japan and China: A Diffusion of Innovation Perspective por Patel, Darshika; University of Auckland,Dufour, Yvon; University of Auckland,Domigan, Neil; Auctus Limited |
5 HPLC Analysis of Mesembrine-Type Alkaloids in Sceletium Plant Material Used as An African Traditional Medicine por Patnala, Srinivas; Rhodes University,Kanfer, Isadore; Faculty of Pharmacy, Rhodes University | 10 Inhibition of Human Cytochrome P450 Metabolism by Blended Herbal Products and Vitamins por Tam, Teresa W; Centre for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, ON,Akhtar, Humayoun; Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph, ON,Arnason, John Thor; Centre for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, ON,Cvijovic, Kosta; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON,Boon, Heather; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON,Cameron, D William; Faculty of Medicine, Univeristy of Ottawa, Ottawa, ON,Drouin, Cathy E; Centre for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, ON,Jaeger, Walter; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna,Tsuyuki, Ross T; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB,Vohra, Sunita; CARE Program, Faculty of Medicine and School of Public Health, University of Alberta, Edmonton, AB,Foster, Brian C; Office of Science, Therapeutic Products Directorate, Health Canada, Ottawa, ON |