| Título: | Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin |
| Autores: |
Hatice Bas Yusuf Kalender; GÜ Fen Edebiyat Fakültesi |
| Fecha: | 2011-11-25 |
| Publicador: | GAZI UNIVERSITY JOURNAL OF SCIENCE |
| Fuente: |
Ver documento |
| Tipo: | Peer-reviewed Article |
| Tema: |
Histology Toxicology Chlorpyrifos, Flavonoids, Antioxidant Enzymes, Histopathology, Heart |
| Descripción: | In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione–S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin- or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren’t protect completely. Key Words: Chlorpyrifos, Flavonoids, Antioxidant Enzymes, Histopathology, Heart |
| Idioma: | Inglés |