Título: | Topical Mitomycin-C versus Subconjunctival 5-Fluorouracil for Management of Bleb Failure |
Autores: |
Mohammad Pakravan; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran Arezoo Miraftabi Shahin Yazdani Nasim Koohestani Mehdi Yaseri |
Fecha: | 2011-05-21 |
Publicador: | Ophthalmic Research Center |
Fuente: |
Ver documento |
Tipo: | |
Tema: | No aplica |
Descripción: | PURPOSE: To compare the efficacy and safety of topical mitomycin C (MMC) drops with that of subconjunctival 5 fluorouracil (5 FU) injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (PT+PCIOL). METHODS: In a randomized comparative study, 37 eyes of 37 patients with impending early bleb failure received MMC 0.02% eye drops for 2 or 4 weeks (19 eyes) or subconjunctival 5 FU injections, 5 mg per dose (18 eyes). Complete success was defined as 5 < IOP ? 18 mmHg without medications. RESULTS: Baseline characteristics were comparable between the study groups. However, there were more cases of combined PT+PCIOL in the MMC group [11 (57.9%) eyes versus 3 (16.7%) eyes, P = 0.017]. Mean preoperative IOP was 20.5±8.85 mmHg in the MMC group and 25.82±11.35 mmHg in the 5 FU group (P = 0.129), which was decreased to 13.2±6.1 and 10.6±4.8 mmHg respectively after 12 months (P = 0.159). There was no significant difference between the study groups in terms of bleb extent (P = 0.170), height (P = 0.178) or vascularity (P = 0.366). At the end of the study, complete success was achieved in 13 eyes (68.4%) in the MMC group and 14 eyes (77.8%) in the 5 FU group (P = 0.714). The survival of success at 8 months (median follow-up) was 89.5% and 86.5% in the MMC and 5 FU groups respectively; the number of glaucoma medications (P = 0.707) and best-corrected visual acuity (P = 0.550) were also comparable. Complication rates were similar in the study groups (P = 0.140). CONCLUSION: Topical MMC 0.02% has comparable safety and efficacy to subconjunctival 5 FU injections for management of early bleb failure. Topical MMC 0.02% drops are more convenient and can be initiated first, while 5 FU injections may be reserved for eyes with an insufficient response to topical MMC. |
Idioma: | Inglés |
1 Short-term Results of Two Treatment Regimens in Ocular Toxoplasmosis: Trimethoprim/Sulfamethoxazole versus Pyrimethamine and Sulfadiazine por Mohammad-Mehdi Sadoughi; Shahid Beheshti University, M.C.,Masoud Soheilian; Shahid Beheshti University, M.C.,Mohammad-Hossein Dehghan; Shahid Beheshti University, M.C.,Hassan Behboudi; Gilan University of Medical Sciences, Rasht,Arash Anisian; Shahid Beheshti University, M.C.,Shahin Yazdani; Shahid Beheshti University, M.C. | 6 Visual Function following Treatment of Optic Neuritis por Majid Abrishami; Mashhad University of Medical Sciences,Mir-Naghi Moosavi; Mashhad University of Medical Sciences,Abbas Azimi-Khorasani; Mashhad University of Medical Sciences,Azardokht Vazifeshenas; Mashhad University of Medical Sciences |
2 Outcomes of Surgical Treatment for Retinal Detachment Resulting from Macular Hole in Highly Myopic Eyes por Amir-Khosro Ghaseminejad; Kerman University of Medical Sciences, Kerman,Masoud Soheilian; Shahid Beheshti University, M.C.,Arash Anisian; Shahid Beheshti University, M.C.,Hamid Ahmadieh; Shahid Beheshti University, M.C.,Mohsen Azarmina; Shahid Beheshti University, M.C. | 7 Changing Concepts in the Surgical Repair of Primary Retinal Detachment: The Odyssey of a Leaking Break (part 1) por Ingrid Kreissig; Department of Ophthalmology, Clinical Faculty, Mannheim University, Heidelberg |
3 Subtenon Carboplatin in the Management of Intraocular Retinoblastoma por Reza Karkhaneh; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Naseh Mohammadi; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Hormoz Chams; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Parvaneh Vosough; Iran University of Medical Sciences, Tehran,Mansour Rezaei; Iran University of Medical Sciences, Tehran,Naser Valaei; Shahid Beheshti University, M.C. | 8 Ocular Complications of Brucellosis: a Case Report por Ali-Reza Lashay; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Mohammad-Reza Manaviat; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Reza Azimi; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Mohammad Riazi; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran |
4 Prophylactic Effects of Mitomycin-C on Regression and Haze Formation in Photorefractive Keratectomy por Hassan Hashemi; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,Mohammad-Reza Taheri; Noor Eye Clinic, Tehran,Akbar Fotouhi; Health Faculty, Tehran University of Medical Sciences, Tehran | 9 Early Results of Autologous Cultivated Limbal Stem Cell Transplantation in Total Limbal Stem Cell Deficiency por Mohammad Ali Javadi; Shahid Beheshti University, M.C.,Bahram Einollahi; Shahid Beheshti University, M.C.,Alireza Baradaran Rafiei; Shahid Beheshti University, M.C.,Hossein Baharvand; Rooyan Research Center, Tehran, Iran,Marzieh Ebrahimi; Rooyan Research Center, Tehran, Iran,Nasrin Rafati; Shahid Beheshti University, M.C.,Mojgan Rezaei Kanavi; Shahid Beheshti University, M.C. |
5 Etiology of Oculomotor Nerve Paralysis por Abdul-Reza Tabassi; Tehran University of Medical Sciences, Tehran,Ali-Reza Dehghani; Isfahan University of Medical Sciences, Isfahan,Hamid Mosayebi; Tehran University of Medical Sciences, Tehran | 10 Amniotic Membrane Transplantation for Congenital Distichiasis por Hossein Saloor; Shahid Beheshti University, M.C.,Maryam Aletaha; Shahid Beheshti University, M.C. |