| Título: | Comparison of Effects of Two Radiotherapy Techniques, Two Tangential / Single Anterior Supra-clavicular Field and Two Tangential / Two Anterior and Posterior Opposed Supra-clavicular Fields on Lung Volumes and Peripheral Oxygen Saturation |
| Autores: |
Ameri, A Mojir Sheibani, Kh Ansari, J |
| Fecha: | 2012-04-16 |
| Publicador: | Shahid Beheshti University of Medical Sciences |
| Fuente: |
Ver documento |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | AbstractBackground: Chest wall irradiation for early breast cancer affects forced vital capacity (FVC), forced expiratory volume in the first second of expiration (FEV1) and may change peripheral oxygen saturation (SpO2). In our institute chest wall is irradiated with a four field technique: two tangential and two oppositional anterior and posterior supraclavicular fields. Regional recurrence in this technique is less than 5 percent.Materials and Methods: We conducted this study to compare changes in FEV1, FVC and SpO2 between standard three field and four fields technique. Materials and methods: We randomized 51 stage I and II breast cancer cases after modified radical mastectomy and completion of chemotherapy in two groups. In group I patients were treated with four field and in group II with three field technique using cobalt 60 teletherapy. Patients with a history of smoking, pulmonary disease, heart disease and any deformities in chest wall were excluded. Patients were stratified due to central lung distance (CLD), fields separation in tangential fields and filed borders defined in standard manner. Radiotherapy dose was 50.4 Gy in 28 fractions. Spirometry and pulse oxymetry was done before, one month after and three months after the completion of radiotherapy.Results: FEV1, FVC and FEV1/FVC showed no significant difference between two groups one month and three months after radiotherapy. Also there was no significant difference in FEV1, FVC, FEV1/FVC one month after radiotherapy comparing with pre-radiotherapy values. There were significant differences in FEV1 and FVC reduction three months after radiotherapy in comparison with pre-radiotherapy values (P<0.001, P<0.006 respectively). SpO2 showed no significant difference between two groups and also in each group after one and three months. Conclusion: Locoregional radiotherapy of chest wall and supraclavicular lymph nodes causes reduction in FEV1 and FVC three months after radiotherapy but there is no significant difference between three field and four fields techniques. We suggest this study be completed by using pulmonary function tests including spirometry and diffusion capacities.Keywords: breast cancer, radiotherapy technique, lung volumes, pulse oximetryReference1. Recht A, silver B , schnitt F , et al . Breast relapse following primary radiation therapy for early breast cancer. Classification, frequency and salvage. Int J Rradiat oncol Biol phys .1985; 11: 1271.2. Hoebers SJP, Borger JH, Hart AA, et al. Primary axillary radiotherapy an axillary treatment in breast conserving therapy for patient with breast carcinoma and cliniclaly negative axillary lymph nodes. Cancer .2000; 88: 1633-1642.3. Zurrida F, Orecchia R, Galimberti V, et al. Axillary radiotherapy instead of axillary dissection: a randomized trial. Ann Surg Oncol .2002; 9: 156-160.4. Chang JH, Vines E, Bertsch H, et al. The impact of a multidisciplinary breast cancer center on recommendations for patient management: the University of Pennsylvania Experience. Cancer. 2001; 91: 1231-1237.5. Kimsey FC, Mendenhall NP. Ewald LM.Is radiation treatment volume a predictor for acute or late effect on pulmonary function? Cancer .1994; 73: 2549-2555.6. Pierce LJ, Moughan J, White J, et al. 1998-1999 patterns of care study process survey of national practice patterns using breast-conserving surgery and radiotherapy in the management of stage I-II breast cancer. Int. J. Radiation Oncology Biol. Phys.2005;62(1):183-192.7. Xiaochun W, TSE Kuan YU, M Salehpour, et al. Breast cancer regional radiation fields for supraclavicular and axillary lymph node treatment: Is a posterior axillary boost field technique optimal? Int. J. Radiation Oncology Biol. Phys.2009;74(1):86-91.8. Gunilla C, Bentel RN, R.T.T, Lawrence B. Marks M.D, Patricia H. Hardenbergh M.D. and Leonard R. Prosnitz M.D. Variability of the depth of supraclavicular and axillary lymph nodes in patients with breast cancer: is a posterior axillary boost field necessary? International Journal of Radiation Oncology*Biology*Physics.2000 Jun.47(3):755-758.9. Gross NJ. Pulmonary effects of radiation therapy. Annals of Internal Med. 1977; 86: 81-92.10. Cho BCJ, Hurkmans CW, Damcn EMF, et al. Intensity modulated versus non – intensity modulated radiotherapy in the treatment of the left breast and. upper internal mammary lymph node chain : a comparative planning study . Radiother Oncol. 2002; 62: 127-136.11. Lund MB, Myhre KL, Mdsom H, et al. The effect on pulmonary function of tangential field technique in radiotherapy for carcinoma of the breast. The British Journal of Radiology 1991, 64; 520 – 523.12. Early Breast cancer trialists collaborative group 2000 trialists meering at oxford. 2000.13. Krueger EA, Fraass BA, Mcshan DL, et al . The potential gains for chest wall and regional nodal irradiation using intensity modulated radiation therapy. Int radiat oncol Biol phys 2001; 51: 123.14. Lind ARM , Rosfors S , wenhberg B , et al. Pulmonary function following adjuvant chemotherapy and radiotherapy for breast cancer and the issue of three – dimensional treatment planning . Radiotherapy and oncology .1998 ; 49:245 – 5915. Chua B, Ung O, Boyages J. Competing considerations in regional nodal treatment for early breast cancer. Breast J .2002; 8: 15-22. |
| Idioma: | Inglés |
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