| Título: | Deprivation level and the risk of colorectal cancer by anatomic subsite in Northern England |
| Autores: |
Movahedi, M Bishop, T Barrett, JH Law, GR |
| Fecha: | 2012-04-23 |
| Publicador: | Shahid Beheshti University of Medical Sciences |
| Fuente: |
Ver documento |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | Abstract: Background: evidence suggests that the incidence of many cancers including bowel cancer vary according to socioeconomic status and education. In case of colorectal cancer, the direction of this association might be even different for anatomical subsites. The aim of this study was to describe the variation in the incidence of colorectal cancer by subsites across North of England and correlate it with community deprivation.Methods: Incidence data were obtained from a population- based cancer registry for the period 1976-2000. Small areas were characterized by their affluence or lack of it, by deriving a Townsend score for each Enumeration District from the 1991 census. The age-standardized incidence rates were calculated for different sites of colorectal cancer for each fifth. The association of each fifth with incidence was also studied using Poisson regression.Results: in men, the age standardized incidence for rectal cancer ranged from 18.3 (for fifth 1, most affluent) to 22.3 (for fifth 5, most deprived) but the trend for proximal cancer was reverse (9.4 for fifth 1 and 8.8 for fifth 5). Poisson models showed a significant inverse association between deprivation level and proximal cancer in both genders. Rectal cancer had a positive significant association with deprivation level in men (RR+1.25, 95% CI, 1.19-1.32).Conclusion: the association of socioeconomic status with proximal cancer was different from that with rectal cancer. Socioeconomic status is not a direct risk factor and might consider as a proxy for life style factors. This indicate that lifestyle correlates of different subsites of bowel cancer differ. Therefore, the different sites of CRC should not be combined in aetiological studies.Keywords: anatomical subsites, colorectal cancer, ecological study, Townsend scoreReferences 1. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer1999; 80(6):827 2. Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer.2002; 101(5):403 3. Cheng X, Chen VW, Steele B, Ruiz B, Fulton J, Liu L, Carozza SE, Greenlee R. Subsite-specific incidence rate and stage of disease in colorectal cancer by race, gender, and C20age group in the United States 1992-1997. Cancer .2001; 92(10):2547 4. Demers RY, Severson RK, Schottenfeld D ,Lazar L. Incidence of colorectal adenocarcinoma by anatomic subsite. An epidemiologic study of time trends and racial differences in the Detroit. Michigan area. Cancer. 1997; 79(3):441 5. Nelson RL, Persky V, Turyk M. Carcinoma in situ of the colorectum. SEER trends by race, gender, and total colorectal cancer. J Surg Oncol. 1999; 71(2):123 Iranian Journal of Cancer Prevention 6. Gonzalez EC, Roetzheim RG, Ferrante JM, Campbell R. Predictors of proximal vs. distal colorectal cancers. Dis Colon Rectum. 2001;44(2):251 7. Nelson RL, Dollear T, Freels S, Persky V. The relation of age, race, and gender to the subsite location of colorectal carcinoma. Cancer. 1997; 80(2):193 8. Devesa SS, Chow WH. Variation in colorectal cancer incidence in the United States by subsite of origin. Cancer. 1993 ;71(12):3819-3826 9. Baquet CR, Commiskey P. Colorectal cancer epidemiology in minorities: a review. J Assoc Acad Minor Phys. 1999;10(3):51 10. Faggiano F, Partanen T, Kogevinas M, Boffetta P. Socioeconomic differences in cancer incidence and mortality. IARC Sci Publ.1997; (138):65 11. Mellemgaard A, Engholm G, Lynge E. High and low risk groups for cancer of colon and rectum in Denmark: multiplicative Poisson models applied to register linkage data. J Epidemiol Community Health.1988; 42(3):249 Deprivation level and the risk of colorectal cancer... 12. Faivre J, Bedenne L, Boutron MC, Milan C, Collonges R, Arveux P. Epidemiological evidence for distinguishing subsites of colorectal cancer. J Epidemiol Community Health. 1989;43(4):356 13. Kee F, Wilson R, Currie S, Sloan J, Houston R, Rowlands B, Moorehead J. Socioeconomic circumstances and the risk of bowel cancer in Northern Ireland. J Epidemiol Community Health. 1996 ;50(6):640 14. Quinn M, Babb P, Brock A, Kirby L, Jones J. Cancer trends in England and Wales, 1950-1999. 2001. Office for National Statistics. 15. Lyratzopoulos G, West CR, Williams EM. Socioeconomic variation in colon cancer tumour factors associated with poorer prognosis. Br J Cancer 2003; 89(5):828, 16. Pollock AM, Vickers N. Breast, lung and colorectal cancer incidence and survival in South Thames Region, 1987-1992: the effect of social deprivation. J Public Health Med. 1997; 19(3):288 |
| Idioma: | Inglés |
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