| Título: | Single versus multiple fractions of palliative radiotherapy for bone metastases: A randomized clinical trial in Iranian patients |
| Autores: |
Amouzegar-Hashemi, Farnaz; Radiation Oncology Dept., Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Behrouzi, Haleh; Radiation Oncology Department, Bessat Hospital, Tehran, Iran Kazemian, Ali; Radiation Oncology Dept., Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Zarpak, Behnam; Statistics and Mathematics Department, Shahed University, Tehran, Iran Haddad, Peiman; Radiation Oncology Dept., Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran |
| Fecha: | 2008-06-17 |
| Publicador: | Multimed Inc. |
| Fuente: |
Ver documento |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | Radiation Oncology; Palliative |
| Descripción: | Aim. To compare single versus multiple fractions of radiotherapy (RT) for palliation of bone metastases in Iranian patients. Patients and methods. Adult patients with painful multiple uncomplicated bone metastases were randomized to 8 Gray (Gy) in a single fraction or 30 Gy in 10 fractions. Patient’s pain was evaluated just before and again one month after the end of RT, and graded on a scale of 1-4. Mean reduction in pain grade and the palliative response were compared in the two groups. Results. Fifty-eight patients (31 multiple fractions, 27 single fraction) were available for evaluation of pain one month after treatment. The reduction in grade of pain was -0.8 to 2.6 with a mean of 1.1. The mean reduction of pain was 1.4 in patients ?50 years and 0.9 in those >50 years (p=0.01). There were 8 (14%) complete responses, 33 (57%) partial responses and 17 (29%) no responses, with a response rate of 71%. The mean reduction in pain and the number of responses in the two groups were not statistically different (p>.01). Patients’ gender, primary tumor, RT site and fractionation did not have any significant effect on reduction of pain. The only factor with a significant effect was age (p=0.002). Conclusions. There was no difference in palliative response among Iranian patients with uncomplicated bone metastases treated with a single fraction versus 10 fractions of palliative RT. Younger patients responded better. |
| Idioma: | Inglés |
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