| Título: | THE IMMUNE RESPONSE OF THE ORGANISM DURING LAPAROSCOPIC AND OPEN CHOLECYSTECTOMY |
| Autores: |
Indira Mehmedagic; University Clinical Center Tuzla, Department of Surgery Sefik Hasukic; University Clinical Center Tuzla, Department of Surgery Deso Mesic; University Clinical Center Tuzla, Department of Surgery Muharem Zildzic; University Clinical Center Tuzla, Department of Gastroenterology Fuad Pasic; University Clinical Center Tuzla, Department of Surgery Sead Serak; University Clinical Center Tuzla, Department of Surgery |
| Fecha: | 2008-06-01 |
| Publicador: | University Clinical Center Tuzla |
| Fuente: |
Ver documento |
| Tipo: |
Original papers prospective study |
| Tema: |
Surgery CRP; Leucocytes; laparoscopic cholecystectomy; open cholecystectomy |
| Descripción: | Introduction: Laparoscopic cholecystectomy (LC) is a method of choice for chronic gallbladder calculus. Surgeon’s experience and sophistication of the work method itself have brought a number of advantages in comparison to open cholecystectomy (OC). Particularly, the advantage corresponds to decreased immune response of the organism on surgical stress. The aim of this study was to define the level of surgical stress through immune response of the organism on stress. Patients and Methods: One hundred patients were involved in the study, 50 of whom were treated by LC method and the other 50 by open method. The patients were of middle age group, between 47 and 57 years of age, mostly female. C-reactive protein was studied as one of the parameters of the organism’s immune response during LC and OC, and also a number of leucocytes, erythrocytes, haemoglobin and hematocrit after LC and OC procedures. C-reactive protein is a biochemical marker, as an organism’s response to stress and the aim of this study is to confirm the CRP values during surgical treatment of chronic calculus of the gallbladder through different surgical methods: conventional or open surgery and laparoscopic surgery which is considered less invasive. Number and frequency of intra-operative and post-operative complications during laparoscopic and open cholecystectomy were also compared. The erythrocytes, haemoglobin and hematocrit and leucocytes, were also determined in both groups of patients with the aim to confirm the hypothesis that the laparoscopic cholecystectomy is a less invasive method compared to the classic or open method. Results and Discussion: The results have confirmed the hypothesis that the laparoscopic cholecystectomy surgical method is less invasive and showed that the value of CRP is much less in post-operative period after LC than OC. In this way, decreased immunological response of the organism on the surgical laparoscopic procedure were confirmed in this study. Decreased value of leucocytes was determined in laparoscopic technique in the post-operative period in comparison to open technique. The number of erythrocytes, hematocrots and haemoglobin were not significantly different in the post-operative period during LC and OC. Complications such as bleeding, bile leakage, subphrenic abscess, post-operative pancreatitis, post-operative wound infection, hernias of post-operative sections and keloid were present more in OC than in LC. Conclusion: Inflammation of early protective homeostatic immune response on post-operative wound characterises the production of C-reactive protein as one of the activities of cellular and humoral mechanisms. This comparative study between laparoscopic and open cholecystectomy in light of immune response of the organism to stress, number and type of intra-operative and post-operative complications, confirmed advantages of laporascopic technique in comparison to open method. |
| Idioma: | bs |
1 Significance of Ear Wax Impaction in School Children por Fuad Brkic; ENT Clinic, University Clinical Center Tuzla | 6 ESTIMATE OF CERTAIN PSYCHIC CHARACTERISTICS AT TESTED DEAF PEOPLE por Husnija Hasanbegovic; University of Tuzla, Education and rehabilitation faculty,Osman Sinanovic; University Clinical Center Tuzla, Clinic for neurology |
2 TREATMENT OF SUBCLINICAL HYPERTHYROIDISM SIGNIFICANTLY REDUCES THE RATE AND SYMPTOMS OF ASSOCIATED CARDIOVASCULAR ABNORMALITIES por Said Gazibegovic; Health Center Odzak, Odzak,Amra Jakubovic-Cickusic; University Clinical Center Tuzla, Department of Nuclear Medicine,Zumreta Kusljugic; University Clinical Center Tuzla, Department of Cardiology,Fahir Barakovic; University Clinical Center Tuzla, Department of Cardiology | 7 MEASUREMENT OF TOTAL AND SPECIFIC IMUNOGLOBULIN E IN ADULT PATIENT WITH BRONCHIAL ASTHMA por Fejzo Dzafic; University Clinical Center Tuzla, Department of laboratory diagnostics,Amer Custovic; University Clinical Center Tuzla, Sector for hygienic and epidemiological survailance,Sead Jamakosmanovic; University Clinical Center Tuzla, Clinic for lung diseases,Damir Sabitovic; University Clinical Center Tuzla, Department of laboratory diagnostics,Indira Sejranic; University Clinical Center Tuzla, Clinic for lung diseases,Munevera Osmic; Health center Tuzla, Polyclinic for lung diseases "Mustafa Sehovic",Suad Dedic; University Clinical Center Tuzla, Clinic for lung diseases,Kemija Prohic; University Clinical Center Tuzla, Clinic for lung diseases,Nerma Sijercic; University Clinical Center Tuzla, Clinic for skin and veneric diseases |
3 IMPACT OF CENTRAL VENOUS PRESSURE AND DIURESIS ON RENAL GRAFT FUNCTION por Semir Imamovic; Department of anesthesiology and reanimatology, University Clinical Center Tuzla,Farid Ljuca; Department of Physiology, Medical Faculty University of Tuzla,Deso Mesic; Department of Surgery, University Clinical Center Tuzla,Sefik Hasukic; Department of Surgery, University Clinical Center Tuzla,Safet Omerovic; Regional Medical Centre "Safet Mujic", Mostar,Mustafa Bazardzanovic; Regional Medical Centre "Safet Mujic", Mostar,Fatima Iljazagic-Halilovic | 8 CHARACTERISTICS OF CHILDHOOD DIFFICULTIES IN BREATHING SYNDROME por Devleta Hadzic; University Clinical Center Tuzla, Paediatric clinic,Nada Mladina; University Clinical Center Tuzla, Paediatric clinic,Mirsada Praso; University Clinical Center Tuzla, Anaestesiology and reanimatology clinic,Selmira Brkic; University of Tuzla, Faculty of Medicine, Department of pathophysiology,Belkisa Colic; University Clinical Center Tuzla, Paediatric clinic |
4 EFFECTS OF HAEMODIALYSIS AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS ON NITRIC OXIDE SERUM CONCENTRATION IN PATIENTS WITH CHRONIC RENAL FAILURE por Amela Matavulj; Department of Physiology School of Medicine University of Banjaluka,Pedja Kovacevic; Department of Physiology School of Medicine University of Banjaluka,Jasminko Huskic; Institute of Physiology and Biochemistry School of Medicine University of Sarajevo,Slavimir Veljkovic; Institute of Physiology School of Medicine University of Nis,Zvezdana Rajkovaca; Department of Physiology School of Medicine University of Banjaluka,Nenad Ponorac; Department of Physiology School of Medicine University of Banjaluka,Zorislava Zagorac; Department of Physiology School of Medicine University of Banjaluka | 9 DETERMINATION OF THE LEVEL OF AMPUTATION IN PATIENTS WITH PERIPHERAL VASCULAR DISEASE por Emir Solakovic; Clinical Center University of Sarajevo, Vascular surgery clinic,Dragan Totic; Clinical Center University of Sarajevo, Vascular surgery clinic,Sid Solakovic; Clinical Center University of Sarajevo, Vascular surgery clinic |
5 PRIMARY IMMUNODEFICIENCY IN CHILDREN IN TUZLA COUNTY por Belkisa Colic-Hadzic; University Clinical Center Tuzla, Clinic for paediatric diseases,Nada Mladina; University Clinical Center Tuzla, Clinic for paediatric diseases,Devleta Hadzic; University Clinical Center Tuzla, Clinic for paediatric diseases,Elvira Konjic; University Clinical Center Tuzla, Clinic for paediatric diseases | 10 EARLY PROGNOSIS OF SUBARACHINOID HAEMORRHAGE por Mirjana Vidovic; University Clinical Center Tuzla, Neurology clinic,Dzevdet Smajlovic; University Clinical Center Tuzla, Neurology clinic,Osman Sinanovic; University Clinical Center Tuzla, Neurology clinic |