| Título: | Evaluation of soybean methanol fraction on acute inflammation. |
| Autores: |
CARRARA, V. da S. AMADO, C. B. MELO, J. O. de MANDARINO, J. M. G. CORTEZ, D. A. G. |
| Fecha: |
2011 2012-02-15 |
| Publicador: | Repositório Acesso Livre à Informação Científica da Embrapa (ALICE) |
| Fuente: |
 |
| Tipo: | Artigo em periódico indexado (ALICE) |
| Tema: | Soja |
| Descripción: |
Soybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P < .05), 1.25 mg/kg by 60.68% (P < .01), and 2.5 mg/kg by 65.68% (P < .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P < .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg. 2011 |
| Idioma: | en |