| Título: | Correlation of Lipid Peroxidation and Glutathione Levels with severity of Systemic Lupus Erythematosus: a Pilot study from Single Center |
| Autores: | Tewthanom, Karunrat; Silpakorn University |
| Fecha: | 2008-07-06 |
| Publicador: | Journal of Pharmacy and Pharmaceutical Sciences |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | Abstract Systemic Lupus Erythematosus (SLE) is a multifactoral chronic autoimmune disease with unidentified etiology. Imbalance of oxidative status is one possible cause of active disease. Plasma malondialdehyde (MDA) and plasma glutathione (GSH) level have been used as a determinate of oxidative status. Limited data has examined these 2 parameters by severity of SLE. Therefore, the purpose of this study was to determine if an association between plasma MDA and plasma GSH level with the severity of SLE . Twenty healthy volunteers (3 Men, 17 women) and 44 SLE patients (2 Men and 42 Women) participated in this study. SLE participants were classified by the severity of disease (mild, moderate or severe). The plasma MDA and plasma Glutathione level were measured. The correlation of plasma MDA and plasma Glutathione levels with the severity of SLE disease were determined. No correlation of plasma MDA level among the 4 groups with different severity of SLE (Control, mild, moderate, and severe of SLE patients) was observed at p |
| Idioma: | Inglés |
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