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Título: |
Protective Effect of Vitamins C and E on Malathion-Induced Nephrotoxicity in Male Rats |
Autores: |
Fatma GOKCE UZUN Yusuf KALENDER |
Fecha: |
2011-04-05 |
Publicador: |
Gazi University Journal of Science |
Fuente: |
![](http://science-h.com/sh/assets/temas/umad/img/tema/globe.png)
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Tipo: |
Peer-reviewed Article |
Tema: |
Histology,Toxicology Organophosphate insecticide, Malathion, Nephrotoxicity, Vitamin C, Vitamin E |
Descripción: |
The male Wistar rats were given malathion and/or vitamin C+vitamin E daily via gavage for 4 weeks. When malathion-, vitamins C+E plus malathion-treated groups were compared to control, body and kidney weights decreased; serum urea, uric acid and creatinine levels increased significantly. Vitamins C+E plus malathion-treated group was compared to malathion-treated group there were statistically decrease in the serum urea level, while no significant changes were observed in other parameters. Light microscopic investigations revealed that both the malathion- and vitamins C+E plus malathion-treated groups exhibited histopathological changes in kidney. It appears that vitamins C and E didn’t ameliorate malathion-induce nephrotoxicity.Keywords: Organophosphate insecticide, Malathion, Nephrotoxicity, Vitamin C, Vitamin E. |
Idioma: |
Inglés |