Título: EVALUATION OF NEW, TRIAZOLOISOQUINOLINE AND PYRAZOLOPYRIDAZINE COMPOUNDS AGAINST THE DESERT LOCUST SCHISTOCERCA GREGARIA (ORTHOPTERA: ACRIDIIDAE)
Autores: Hassanain, Hamdy M.; Chemistry Department, Faculty of science, Cairo University
Nassar, Mamdouh I.; Entomology Department, Faculty of Science, Cairo University
Fecha: 2013-12-05
Publicador: International Journal of Entomological Research
Fuente:
Tipo: info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Tema: [1,2,4]Triazolo[3,4-a]isoquinolines, Enaminones, Hydrazinolysis, Hydrazonoyl Chlorides, Cycloaddition Reactions. Bioactivities study, desert locust, Schistocerca gregaria
Descripción: The present study deals with the bioactivities of 3-Acetyl[1,2,4]triazolo[3,4-a]isoquinoline was used to prepare a novel enaminone 5. Reactions of 5 with hydrazonoyl halides 6 gave triazoloisoquinolines 10 with a carbonylpyrazole as a side chain. Hydrazinolysis of 10 gave the pyrazolopyridazines 12. Bioactivity of these compounds was applied on 4th nymphal instar of the desert locust Schistocerca gregaria. Results clearly showed that the compound 12b was the most effective against 4th nymphal instars, while the compound 12a has the lowest effect. Meanwhile the chemical compounds, 10b and 10a were intermediate bioactive. In order of toxicity the lethal concentration was 0.31, 0.37, 0.46, and 0.57 of the chemical compounds 12b, 10b, 10a  and 12a respectively. On the other hand some deformation of the treated nymphs was observed by the effect of different chemical compounds due to molting inhibition for the next stages
Idioma: Inglés

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