| Título: | Fixation probability for competing selective sweeps |
| Autores: |
Cuthbertson, Charles; Morgan Stanley Etheridge, Alison; University of Oxford Yu, Feng; University of Bristol |
| Fecha: | 2012-01-01 |
| Publicador: | Electronic journal of probability |
| Fuente: |
 |
| Tipo: | Peer-reviewed Article |
| Tema: |
selective sweep; fixation probability; double mutant 92D15 |
| Descripción: | We consider a biological population in which a beneficial mutation is undergoing a selective sweep when a second beneficial mutation arises at a linked locus. We investigate the probability that both mutations will eventually fix in the population. Previous work has dealt with the case where the second mutation to arise confers a smaller benefit than the first. In that case population size plays almost no rôle. Here we consider the opposite case and observe that, by contrast, the probability of both mutations fixing can be heavily dependent on population size. Indeed the key parameter is $rN$, the product of the population size and the recombination rate between the two selected loci. If $rN$ is small, the probability that both mutations fix can be reduced through interference to almost zero while for large $rN$ the mutations barely influence one another. The main rigorous result is a method for calculating the fixation probability of a double mutant in the large population limit. |
| Idioma: | Inglés |
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